Histological and molecular alterations in inflammatory myopathies [Alteraciones histológicas y moleculares en miopatías inflamatorias]

dc.contributorVázquez del Mercado Espinosa, M., Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, CUCS, Universidad de Guadalajara, Jalisco, Mexico; Arana Argaez, V., Universidad Autónoma de Mérida, Mérida, Yucatán, Mexico; Heron Petri, M., Instituto de Investigacion en Reumatologia y del Sistema Musculo Esqueletico, CUCS, Universidad de Guadalajara, Jalisco, Mexico; Aguilar Arreola, J., OPD Hospital Civil Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico
dc.creatorVazquez del Mercado Espinosa, M.
dc.creatorArana Argaez, V.
dc.creatorHeron Petri, M.
dc.creatorAguilar Arreola, J.
dc.date.accessioned2015-11-19T18:50:14Z
dc.date.accessioned2023-07-04T00:58:14Z
dc.date.available2015-11-19T18:50:14Z
dc.date.available2023-07-04T00:58:14Z
dc.date.created2015-11-19T18:50:14Z
dc.date.issued2009
dc.identifierhttp://hdl.handle.net/20.500.12104/65302
dc.identifier10.1016/j.reuma.2009.07.007
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-71849102924&partnerID=40&md5=9108493d58ce9cf39717919293c8cdf3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7255842
dc.description.abstractThe histological findings in muscle biopsies of inflammatory myopathies have been divided into 2 groups: A) Endomisial infiltrates mainly by T CD8+, CD4+ and macrophages and B) Perivascular infiltrates by CD4+, B cells and macrophages. The first kind of infiltrate suggests an immune reaction against muscle fibers very common in PM and inclusion body myositis, On the other hand the perivascular infiltrate is a hallmark of DM. It has ben shown that autoantigens related with myopathies such as Mi-2, Jo-1, OJ, PL12, Ku, PM/Scl are able to suffer proteolytic cleavage by granzyme B and other stimulus induced by cytotoxic T cells. In this chapter we will review the histological and molecular findings of inflammatory myopathies but we will also discuss a special group of myopathies related to the presence of antibodies against the SRP complex, in particular the SRP72 and SRP54 antibodies, which are associated with a poor prognosis and clinical outcome and present an inadequate response to conventional treatment. © 2009 Elsevier España, S.L. All rights reserved.
dc.relationReumatologia Clinica
dc.relation5
dc.relationSUPPL. 3
dc.relation20
dc.relation22
dc.relationScopus
dc.titleHistological and molecular alterations in inflammatory myopathies [Alteraciones histológicas y moleculares en miopatías inflamatorias]
dc.typeArticle


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