Short (GT)n microsatellite repeats in the heme oxygenase-1 gene promoter are associated with antioxidant and anti-inflammatory status in Mexican pediatric patients with sepsis

Abstract

In this work we define a shape entropy by calculating the Shannon's entropy of the shape function. This shape entropy and its linear response to the change in the total number of electrons of the molecule are explored as descriptors of bonding properties. Calculations on selected molecular systems were performed. According to these, shape entropy properly describes electron delocalization while its linear response to ionization predicts changes in bonding patterns. The derivative of the shape entropy proposed turned out to be fully determined by the shape function and the Fukui function. " 2013 Springer-Verlag Berlin Heidelberg.",,,,,,"10.1007/s00894-012-1725-4",,,"http://hdl.handle.net/20.500.12104/44518","http://www.scopus.com/inward/record.url?eid=2-s2.0-84876407249&partnerID=40&md5=e6e022519bf995a45470bebd7edb11e9",,,,,,"4",,"Journal of Molecular Modeling",,"1677

1683",,"19",,"Scopus

WOS",,,,,,"Electron delocalization; Fukui function; Shannon's entropy; Shape function",,,,,,"Shape entropy's response to molecular ionization",,"Article" "46323","123456789/35008",,"Schneiter, E.M., Instituto de Ciencias Nucleares, Ciudad Universitaria, Apartado Postal 70-543, CP 04510, México D.F, Mexico; De La Fuente, E., Departamento de Física, CUCEI, Universidad de Guadalajam, Av. Revolution, 1500 S/R Guadalajam, Jalisco, Mexico; Velázquez, P.F., Instituto de Ciencias Nucleares, Ciudad Universitaria, Apartado Postal 70-543, CP 04510, México D.F, Mexico",,"Schneiter, E.M.

De La Fuente, E.

Velazquez, P.F.",,"2006",,"We present a single-explosion model study of the 3C 400.2 supernova remnant (SNR), made with two-dimensional axisymmetric simulations. The numerical simulations were made with the adaptive grid code YGUAZ -A. Several initial scenarios have been tested in order to reproduce the centrally peaked X-ray emission observed for this remnant. This study reveals that the explosion of the SN inside a pre-existing stellar wind bubble successfully generates the observed morphology, when thermal conduction is included in the model. The best morphological fit is obtained at an evolution time of 21000 yr, when the total luminosity is 1.2 1034 erg s-1. 2006 RAS.",,,,,,"10.1111/j.1365-2966.2006.10652.x",,,"http://hdl.handle.net/20.500.12104/44544","http://www.scopus.com/inward/record.url?eid=2-s2.0-33747519980&partnerID=40&md5=9f17bdaf08b099872c0b3cb84d9fdf3d",,,,,,"1",,"Monthly Notices of the Royal Astronomical Society",,"369

374",,"371",,"Scopus

WOS",,,,,,"Hydrodynamics; Methods: numerical; Supernova remnants; X-rays: individual: 3C 400.2",,,,,,"Simulated X-ray emission from a single-explosion model for a supernova remnant 3C 400.2",,"Article" "46302","123456789/35008",,"Vázquez-Armenta, G., Doctorado en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, JAL, Mexico, Tecnológico de Monterrey, Guadalajara, JAL, Mexico; González-Leal, N., Servicio Infectología Pediátrica, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Universidad de Guadalajara, Guadalajara, JAL, Mexico, Hospital Infantil Universitario 'Rafael Henao Toro', Manizales, Caldas, Colombia; la Torre, M.J.V., Servicio Infectología Pediátrica, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Universidad de Guadalajara, Guadalajara, JAL, Mexico; Muñoz-Valle, J.F., Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, JAL, Mexico; Ramos-Márquez, M.E., Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, JAL, Mexico; Hernández-Cañaveral, I., Departamento de Microbiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, JAL, Mexico; Plascencia-Hernández, A., Servicio Infectología Pediátrica, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Universidad de Guadalajara, Guadalajara, JAL, Mexico; Siller-López, F., Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, JAL, Mexico, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia",,"Vazquez-Armenta, G.

Gonzalez-Leal, N.

la Torre, M.J.V.

Munoz-Valle, J.F.

Ramos-Marquez, M.E.

Hernandez-Canaveral, I.

Plascencia-Hernandez, A.

Siller-Lopez, F.",,"2013",,"An adequate immune and antioxidant response is a key to the resolution of sepsis. Heme oxygenase-1 (HMOX1) is a stress protein with a polymorphic (GT)n repeat in its gene promoter that regulates its expression in response to oxidative injury, such as that present in sepsis. HMOX1 is the rate-limiting enzyme of heme degradation, and the heme breakdown products, CO, Fe, and bilirubin, are considered to be biologically active metabolites with direct or indirect antioxidant and anti-inflammatory properties. In this study, we investigated the inflammatory and antioxidant response and the relationship with the HMOX1 levels and HMOX1 polymorphism in Mexican septic pediatric patients. In a case-control pilot study, we enrolled 64 septic patients and 72 hospitalized control patients without a diagnosis of sepsis. DNA extracted from buffy coat was genotyped for HMOX1 (GT)n polymorphism by PCR and markers of antioxidant and inflammatory status were quantified in plasma by analysis of the oxygen radical absorbance capacity (ORAC), protein carbonyl (PC), interleukin (IL) 6, IL10, and HMOX1 levels. In septic children, oxidative and inflammatory markers were elevated, and HMOX1 levels were positively correlated with IL10 levels. Genotypic and allelic distribution of HMOX1 polymorphism showed no difference between groups. HMOX1 short-allele septic carriers (< 25 GT repeats) presented favorable ORAC, PC and IL10 levels. This study confirms that an active response against pediatric sepsis involves the expression of HMOX1 and IL10, suggesting that the high antioxidant status associated with HMOX1 short-allele septic carriers might provide a beneficial environment for sepsis resolution. " 2013 Tohoku University Medical Press.