Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers
dc.contributor | Sánchez-Vázquez, R., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Briseño-Rodríguez, G., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Cardona-Muñoz, E.G., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Gálvez-Gastélum, F.J., Instituto de Biología Molecular en Medicina, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Sierra Mojada, 950, Col. Independencia; Totsuka-Sutto, S.E., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Garcia-Benavides, L., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Instituto de Biología Molecular en Medicina, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico | |
dc.creator | Sanchez-Vazquez, R. | |
dc.creator | Briseno-Rodriguez, G. | |
dc.creator | Cardona-Munoz, E.G. | |
dc.creator | Galvez-Gastelum, F.J. | |
dc.creator | Totsuka-Sutto, S.E. | |
dc.creator | Garcia-Benavides, L. | |
dc.date.accessioned | 2015-11-19T18:50:42Z | |
dc.date.accessioned | 2023-07-03T23:04:30Z | |
dc.date.available | 2015-11-19T18:50:42Z | |
dc.date.available | 2023-07-03T23:04:30Z | |
dc.date.created | 2015-11-19T18:50:42Z | |
dc.date.issued | 2008 | |
dc.identifier | http://hdl.handle.net/20.500.12104/65785 | |
dc.identifier | 10.1177/0003319707303700 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-39149123121&partnerID=40&md5=b757ea6230dee523fca4821d8081cb2f | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7248061 | |
dc.description.abstract | Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement. © 2008 Sage Publications. | |
dc.relation | Angiology | |
dc.relation | 59 | |
dc.relation | 1 | |
dc.relation | 64 | |
dc.relation | 71 | |
dc.relation | Scopus | |
dc.relation | WOS | |
dc.title | Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers | |
dc.type | Article |