| dc.contributor | Bayod, S., Unitat de Farmacologia i Farmacognòsia. Facultat de Farmàcia, Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, 08028, Spain, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain; Guzmán-Brambila, C., División de Biotecnología y Salud, Escuela de Medicina, Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Guadalajara, Guadalajara, Jalisco 45201, Mexico; Sanchez-Roige, S., School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom; Lalanza, J.F., Institut de Neurociències, Departamento. de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain; Kaliman, P., Instituto de Investigaciones Biomédicas de Barcelona IIBB-CSIC, c/Rosselló 161, 6th floor, Barcelona, 08036, Spain; Ortuño-Sahagun, D., Instituto de Investigación en Ciencias Biomédicas (IICB), CUCS, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Escorihuela, R.M., Institut de Neurociències, Departamento. de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain; Pallàs, M., Unitat de Farmacologia i Farmacognòsia. Facultat de Farmàcia, Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, 08028, Spain, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain | |
| dc.description.abstract | Regular physical exercise mediates health and longevity promotion involving Sirtuin 1 (SIRT1)-regulated pathways. The anti-aging activity of SIRT1 is achieved, at least in part, by means of fine-tuning the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway by preventing the transition of an originally pro-survival program into a pro-aging mechanism. Additionally, SIRT1 promotes mitochondrial function and reduces the production of reactive oxygen species (ROS) through regulating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), the master controller of mitochondrial biogenesis. Here, by using senescence-accelerated mice prone 8 (SAMP8) as a model for aging, we determined the effect of wheel-running as a paradigm for long-term voluntary exercise on SIRT1-AMPK pathway and mitochondrial functionality measured by oxidative phosphorylation (OXPHOS) complex content in the hippocampus and cortex. We found differential activation of SIRT1 in both tissues and hippocampal-specific activation of AMPK. These findings correlated well with significant changes in OXPHOS in the hippocampal, but not in the cerebral cortex, area. Collectively, the results revealed greater benefits of the exercise in the wheel-running intervention in a murine model of senescence, which was directly related with mitochondrial function and which was mediated through the modulation of SIRT1 and AMPK pathways. © 2014 Springer Science+Business Media New York. | |
