Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population

dc.contributorRamos-Silva, A., Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social SecurityGuadalajara, Jalisco, Mexico, Health Sciences University Center, University of GuadalajaraGuadalajara, Jalisco, Mexico; Figuera, L.E., Genetics Division, Western Biomedical Research Center, Western National Medical CenterGuadalajara, Jalisco, Mexico; Soto-Quintana, O.M., Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social SecurityGuadalajara, Jalisco, Mexico, Health Sciences University Center, University of GuadalajaraGuadalajara, Jalisco, Mexico; Puebla-Pérez, A.M., Inmmunopharmacology Laboratory, Exact and Engineering Sciences University Center, University of GuadalajaraGuadalajara, Jalisco, Mexico; Ramírez-Patiño, R., Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social SecurityGuadalajara, Jalisco, Mexico, Health Sciences University Center, University of GuadalajaraGuadalajara, Jalisco, Mexico; Gutiérrez-Hurtado, I., Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social SecurityGuadalajara, Jalisco, Mexico, Health Sciences University Center, University of GuadalajaraGuadalajara, Jalisco, Mexico; Carrillo-Moreno, D.I., Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social SecurityGuadalajara, Jalisco, Mexico, Health Sciences University Center, University of GuadalajaraGuadalajara, Jalisco, Mexico; Zúñiga-González, G.M., Mutagenesis Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social SecurityGuadalajara, Jalisco, Mexico; Dávalos-Rodríguez, I.P., Genetics Division, Western Biomedical Research Center, Western National Medical CenterGuadalajara, Jalisco, Mexico; Gallegos-Arreola, M.P., Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social SecurityGuadalajara, Jalisco, Mexico
dc.creatorRamos-Silva, A.
dc.creatorFiguera, L.E.
dc.creatorSoto-Quintana, O.M.
dc.creatorPuebla-Perez, A.M.
dc.creatorRamirez-Patino, R.
dc.creatorGutierrez-Hurtado, I.
dc.creatorCarrillo-Moreno, D.I.
dc.creatorZuniga-Gonzalez, G.M.
dc.creatorDavalos-Rodriguez, I.P.
dc.creatorGallegos-Arreola, M.P.
dc.date.accessioned2015-09-15T17:23:22Z
dc.date.accessioned2023-07-03T22:10:41Z
dc.date.available2015-09-15T17:23:22Z
dc.date.available2023-07-03T22:10:41Z
dc.date.created2015-09-15T17:23:22Z
dc.date.issued2015
dc.identifierhttp://hdl.handle.net/20.500.12104/39656
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84928636808&partnerID=40&md5=adf610e34755aed15cdffe50b686f789
dc.identifierhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25966173
dc.identifier10.4238/2015.April.27.16
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7244292
dc.description.abstractThe methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland. We examined the role of the C677T polymorphism in the MTHFR gene by comparing the C677T genotypes of 339 healthy Mexican women with those of 497 Mexican women with breast cancer (BC). The genotype frequencies observed in the controls and patients with BC were 10 and 21% for 677TT; 41 and 36% for 677CT; and 49 and 43% for 677CC, respectively. The odds ratio (OR) for the 677TT genotype was 2.5, with a 95% confdence interval (95%CI) of 1.6-3.8; P = 0.0001. The positive association was also evident when the distributions of the 677TT genotype in control and patients affected within the following two categories were compared to alcohol consumption (OR = 0.41; 95%CI = 0.19-0.86; P = 0.018); and high level glutamate-oxaloacetate transaminase (SGOT) (OR = 0.36; 95%CI = 0.15-0.83, P = 0.017). These results suggest that the 677TT genotype of the C677T polymorphism in the MTHFR gene is associated with BC susceptibility in the Mexican population. Zapotitlán FUNPEC-RP.
dc.relationScopus
dc.relationMEDLINE
dc.relationGenetics and Molecular Research
dc.relation14
dc.relation2
dc.relation4015
dc.relation4026
dc.titleAssociation of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population
dc.typeArticle


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