Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients

Abstract

Small scale spatial patterns (<10. km) in nearshore internal wave fields are rarely reported on, yet can have a large impact on nearshore mixing and productivity. In this study, the spatial pattern of internal wave characteristics were explored in Todos Santos Bay, Baja California (Mexico), using time series of temperature and currents from moored and towed thermistor chains and acoustic profiling current meters, as well as cross-shore transects with a towed undulating CTD system. Spectra of temperature and currents showed significant spatial variability within the bay, with the northern sector dominated by the internal tidally-forced semidiurnal signal, and the southern sector dominated by wind-forced, subinertial, baroclinic, diurnal fluctuations, which decreased with distance from shore. Semidiurnal internal tidal waves were generated by the barotropic tide at various sites on the continental slope to the west of the bay. They traveled toward the NE and reached the observation site in the northern part of the bay, after bouncing once or twice off the surface and the bottom. Despite the narrowness of the shelf, the semidiurnal internal tides at this site presented a first-mode structure, although not completely formed at times. On average, the semidiurnal internal waves had a ~9. km wavelength, traveled in the form of an arc, and propagated with a phase velocity of ~20. cm/s. When they reached shallow waters near the coast, they disintegrated rapidly into groups of short, nonlinear internal waves, with 15-20. m amplitudes, 5-20. min periods, and 50-200. m wavelengths. The spatial patterns found in this study are most likely due to variability in distance from generation sites, complex bottom topography, and small scale (<10. km) spatial variability in meteorological conditions such as winds. " 2014 Elsevier Ltd.",,,,,,"10.1016/j.csr.2014.01.015",,,"http://hdl.handle.net/20.500.12104/44667","http://www.scopus.com/inward/record.url?eid=2-s2.0-84896837948&partnerID=40&md5=45f799bace53a5badac808beb3d05d90",,,,,,,,"Continental Shelf Research",,"1

15",,"78",,"Scopus

WOS",,,,,,"Diurnal wind forcing; Internal tides; Narrow shelf; NW Mexico; Semidiurnal tidal forcing",,,,,,"Spatial variability of internal waves in an open bay with a narrow steep shelf in the Pacific off NW Mexico",,"Article" "46504","123456789/35008",,"Gómez-Lomelí, Z.M., Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Salud Pública, Monte Olimpo 1540, Col. Independencia, 44340 Guadalajara, Jalisco, Mexico; César Dávalos-Guzmán, J., Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Salud Pública, Monte Olimpo 1540, Col. Independencia, 44340 Guadalajara, Jalisco, Mexico; Celis-de La Rosa, A.D.J., Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Salud Pública, Monte Olimpo 1540, Col. Independencia, 44340 Guadalajara, Jalisco, Mexico; Orozco-Valerio, M.D.J., Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Salud Pública, Monte Olimpo 1540, Col. Independencia, 44340 Guadalajara, Jalisco, Mexico",,"Gomez-Lomeli, Z.M.

Cesar Davalos-Guzman, J.

Celis-de La Rosa, A.D.J.

Orozco-Valerio, M.D.J.",,"2010",,"Objective: To identify socio-demographic characteristics and general health conditions among senior citizens working as volunteer packers in a supermarket chain in Mexico. Material and methods: From May to July 2008 we carried out a cross-sectional analysis in 416 volunteers aged 60 or more years. Results: Mean age was 69.4 years, (range 60-87). Mean level of schooling was elementary school. Men's prior occupation was in the formal sector of the economy vs. women participants who were not. Men were mostly from lower middle class strata and women from lower strata. Most participant's self-perception of health was good although there was an inherent risk of developing obesity. Depression rating scale scores were within normal limits. They had sought work as packers due to financial constraints. Conclusions: Senior citizens working as paid volunteers seems to promote their physical, mental, social and financial well being. Our findings suggest gender differences within the context of a bleak socio-economic and epidemiological panorama.",,,,,,,,,"http://hdl.handle.net/20.500.12104/44725","http://www.scopus.com/inward/record.url?eid=2-s2.0-77954251935&partnerID=40&md5=e852b0c2ad9a31338b58598825640566",,,,,,"2",,"Gaceta Medica de Mexico",,"90

97",,"146",,"Scopus",,,,,,"Elderly; Functionality; Public health",,,,,,"State of functionality of senior citizens working as packers in supermarkets [Estado de funcionalidad de adultos mayores empacadores en tiendas de autoservicio]",,"Article" "46475","123456789/35008",,"Fierro, N.A., Unidad de InmunovirologíaGuadalajara, Jalisco, Mexico, Departamento de FisiologiaGuadalajara, Jalisco, Mexico; González-Aldaco, K., Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Jalisco, Mexico, Departamento de Biología MolecularGuadalajara, Jalisco, Mexico; Torres-Valadez, R., Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Jalisco, Mexico, Departamento de Biología MolecularGuadalajara, Jalisco, Mexico; Trujillo-Trujillo, M.E., Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Jalisco, Mexico, Departamento de Biología MolecularGuadalajara, Jalisco, Mexico; Roman, S., Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Jalisco, Mexico, Departamento de Biología MolecularGuadalajara, Jalisco, Mexico; Trujillo-Ochoa, J.L., Unidad de InmunovirologíaGuadalajara, Jalisco, Mexico, Departamento de FisiologiaGuadalajara, Jalisco, Mexico; Panduro, A., Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Jalisco, Mexico, Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico

Panduro-Cerda, Arturo., Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud",,"Fierro, N.A.

Gonzalez-Aldaco, K.

Torres-Valadez, R.

Trujillo-Trujillo, M.E.

Roman, S.

Trujillo-Ochoa, J.L.

Panduro-Cerda, Arturo",,"2015",,"The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggests that cytokine profiles may predict disease outcome during HCV infection. " 2015, Fundacao Oswaldo Cruz. All rights reserved.