Análisis de microbiota intestinal en población adulta colombiana asociada a factores de riesgo de diabetes mellitus tipo 2 y obesidad.

dc.contributorCalderón Ozuna, Martha Nancy
dc.contributorBioquímica y Biología Molecular de las Micobacterias
dc.contributorhttps://orcid.org/0000-0003-2579-9907
dc.creatorCruz Hernández, Claudia Lorena
dc.date.accessioned2023-02-15T16:56:47Z
dc.date.accessioned2023-06-07T00:27:00Z
dc.date.available2023-02-15T16:56:47Z
dc.date.available2023-06-07T00:27:00Z
dc.date.created2023-02-15T16:56:47Z
dc.date.issued2023-02-03
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/83486
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6651976
dc.description.abstractLa microbiota intestinal es la comunidad de microorganismos vivos del tracto gastrointestinal, la pérdida del equilibrio en ésta se ha relacionado con diabetes mellitus tipo 2 (DM2) y obesidad; dos enfermedades de alta comorbilidad en las últimas décadas. El objetivo fue estudiar perfiles filogenéticos de la microbiota intestinal en adultos colombianos entre 40 y 70 años. Se realizaron jornadas de salud para el reclutamiento de voluntarios; se realizó valoración clínica a 535 participantes, que incluyó medidas de composición corporal y antropometría. Se aplicó la escala de riesgo FINDRISC y se extrajo muestra sanguínea para análisis bioquímicos; se recibió una muestra de materia fecal, para la extracción del ADN de la microbiota intestinal. El 70% de la población enrolada presentó alteración en el índice de masa corporal (IMC), el 50% riesgo a desarrollar DM2 y el 66% presentó riesgo metabólico. Se seleccionaron 85 voluntarios para el estudio de microbiota intestinal, mediante secuenciación del gen 16S rRNA, utilizando la plataforma Ion Torrent de ThermoFisher. Los análisis bioinformáticos se realizaron sobre los resultados de 40 muestras discriminadas según IMC y el comportamiento glucémico, utilizando el Software QIIME 2TM, los análisis de biodiversidad y de biomarcadores microbianos se realizaron en el Software MicrobiomeAnalyst. Los filos bacterianos más abundantes fueron Firmicutes (49%), Bacteroidetes (39%) y Proteobacteria (7%); se observó que predominaron taxones microbianos asociados a un patrón de alimentación occidental. Se logró identificar catorce biomarcadores microbianos diferentes en cada subgrupo; se encontró relación estadística significativa entre familias, géneros y especies con diferentes parámetros clínicos asociados a disbiosis y de riesgo metabólico. (Texto tomado de la fuente)
dc.description.abstractThe gut microbiota is the community of living microorganisms of the gastrointestinal tract, the loss of balance in it has been related to type 2 diabetes mellitus (DM2) and obesity; two diseases with high comorbidity in recent decades. The objective was to study phylogenetic profiles of the intestinal microbiota in Colombian adults between 40 and 70 years old. Health sessions were held to recruit volunteers; A clinical assessment was performed on 535 participants, which included measurements of body composition and anthropometry. The FINDRISC risk scale was applied, and a blood sample was taken for biochemical analysis; a stool sample was received for DNA extraction from the intestinal microbiota. 70% of the enrolled population presented an alteration in the body mass index (BMI), 50% risk of developing DM2 and 66% presented metabolic risk. 85 volunteers were selected for the intestinal microbiota study, by sequencing the 16S rRNA gene, using ThermoFisher's Ion Torrent platform. The bioinformatic analyzes were carried out on the results of 40 samples discriminated according to BMI and glycemic behavior, using the QIIME 2TM Software, the biodiversity and microbial biomarker analyzes were carried out in the MicrobiomeAnalyst Software. The most abundant bacterial phyla were Firmicutes (49%), Bacteroidetes (39%) and Proteobacteria (7%); it was observed that microbial taxa associated with a western feeding pattern predominated. Fourteen different microbial biomarkers were identified in each subgroup; a significant statistical relationship was found between families, genera and species with different clinical parameters associated with dysbiosis and metabolic risk.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ciencias - Maestría en Ciencias - Microbiología
dc.publisherFacultad de Ciencias
dc.publisherBogotá, Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAnálisis de microbiota intestinal en población adulta colombiana asociada a factores de riesgo de diabetes mellitus tipo 2 y obesidad.
dc.typeTrabajo de grado - Maestría


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