Quimeras peptídicas: una alternativa sintética para potenciar la actividad antimicrobiana de péptidos

dc.contributorGarcia Castañeda, Javier Eduardo
dc.creatorSalamanca Saavedra, Yeimy Cristina
dc.date.accessioned2023-03-06T20:51:25Z
dc.date.accessioned2023-06-06T23:57:56Z
dc.date.available2023-03-06T20:51:25Z
dc.date.available2023-06-06T23:57:56Z
dc.date.created2023-03-06T20:51:25Z
dc.date.issued2022
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/83594
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6651651
dc.description.abstractLa emergencia provocada por la resistencia microbiana a los medicamentos disponibles actualmente ha motivado el desarrollo de agente terapéuticos que superen esta limitación. Los péptidos antimicrobianos (PAMs) son una alternativa que ha ganado relevancia ya que poseen actividad antimicrobiana contra un amplio espectro de microorganismos y, anticancerígena contra líneas celulares de diferentes tipos de cáncer a través de mecanismos de acción únicos. Una de las alternativas que permite potenciar la actividad biológica de los PAMs es la síntesis de quimeras peptídicas, que permite la obtención de moléculas que no son producidas de forma natural y actúan a través de mecanismos de acción combinados generando aumento de la selectividad y actividad biológica entre 1,5 y 10 veces. En este sentido, el diseño de las quimeras puede combinar péptidos penetrantes en las células con péptidos activos biológicamente para generar péptidos híbridos con doble función. Dentro de la revisión bibliográfica se incluyen también diferentes métodos de obtención de PAMs como la obtención a partir de fuentes naturales, que se considera costosa y de baja aplicación en el campo industrial, la producción a través del método recombinante mediante la manipulación genética de microorganismos como E. Coli que se convierten en productores de PAMs, lo que lo hace un método económico y rápido, aunque presenta limitaciones en el diseño de secuencias con AA no naturales, y por último el método de síntesis química en fase sólida (SPPS) que es el de mayor popularidad ya que permite obtener péptidos sin limitaciones en el diseño de las secuencias, es un método escalable y que genera altos rendimientos. (Texto tomado de la fuente).
dc.description.abstractThe emergence caused by microbial resistance to currently available drugs has motivated the development of therapeutic agents that overcome this limitation. Antimicrobial peptides (AMPs) are an alternative that has gained relevance because they have antimicrobial activity against a wide spectrum of microorganisms and anticancer activity against cell lines of different types of cancer through unique mechanisms of action. One of the alternatives that allows enhancing the biological activity of PAMs is synthesis of peptide chimeras, which allows obtaining molecules that are not produced naturally and act through combined mechanisms of action, generating an increase in selectivity and biological activity. between 1.5 and 10 times. In this regard, the design of chimeras can combine cell-penetrating peptides with biologically active peptides to generate hybrid peptides with dual functions. Within the bibliographic review, different methods of obtaining PAMs are also included, such as obtaining from natural sources, which is considered expensive and of low application in the industrial field, production through the recombinant method through the genetic manipulation of microorganisms such as E. Coli that become producers of PAMs, which makes it an economical and fast method, although it has limitations in the design of sequences with non-natural AA, and finally the solid phase chemical synthesis method (SPPS) that is the most popular since it allows obtaining peptides without limitations in the design of the sequences, it is a scalable method that generates high yields.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ciencias - Maestría en Ciencias - Química
dc.publisherFacultad de Ciencias
dc.publisherBogotá, Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsReconocimiento 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleQuimeras peptídicas: una alternativa sintética para potenciar la actividad antimicrobiana de péptidos
dc.typeTrabajo de grado - Maestría


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