dc.contributorMogollón Galvis, José Dario
dc.creatorOrtiz Castro, Luis Felipe
dc.date.accessioned2023-04-21T13:58:48Z
dc.date.accessioned2023-06-06T22:52:54Z
dc.date.available2023-04-21T13:58:48Z
dc.date.available2023-06-06T22:52:54Z
dc.date.created2023-04-21T13:58:48Z
dc.date.issued2023-03-28
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/83750
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6650948
dc.description.abstractEl complejo respiratorio porcino (PRC) es una enfermedad multifactorial y compleja en cerdos en crecimiento y finalización que causa grandes pérdidas en la industria porcina en todo el mundo. El objetivo de este estudio fue determinar los diferentes patrones neumónicos presentes por estudios morfológicos y establecer su gravedad en cerdos de engorde pertenecientes a una granja de la parte oriental de Colombia. Se colectaron muestras de pulmones y nódulos linfáticos de cerdos en la planta de beneficio. Estos pulmones fueron examinados por un profesional en patología externo para detectar lesiones craneoventrales de bronconeumonía (BN). De 1000 cerdos examinados, solo se recolectaron 153 muestras. Cincuenta y dos cerdos fueron seleccionados como controles porque no presentaban lesiones macroscópicas y ciento un cerdos fueron llamados casos porque presentaban lesiones craneoventrales neumónicas. Las lesiones histopatológicas revelaron en el grupo control la presencia de neumonía intersticial (NI) en el 59,62% de los casos, y dos patrones neumónicos combinados en el 19,23% de los casos (Neumonía Bronco-Intersticial y Neumonía Intersticial – NBI-NI). Cuando se estudió el grupo de casos, se identificaron múltiples patrones neumónicos. La combinación más frecuente de patrón microscópico fue Bronconeumonía Supurativa (BNS) y Neumonía Bronco-Intersticial (NBI) en el 57,43% de los casos estudiados (BNS-NBI), seguido de la combinación de tres patrones neumónicos Bronconeumonía Supurativa + Neumonía Broncointersticial + Neumonía Intersticial en el 26,73% de los casos (BNS-NBI-NI). Estos hallazgos sugirieron que ocurrieron múltiples interacciones entre los patógenos del Complejo Respiratorio Porcino (PRC) y con una gravedad variable entre ellos. Además, las lesiones detectadas en la planta de beneficio serían diferentes si se comparan con el examen histopatológico. Por lo tanto, los estudios histopatológicos ofrecieron una idea más precisa de las lesiones reales presentes cuando ocurre neumonía clínica. Se puede sugerir, que la Neumonía Bronco-Intersticial compatible con M. hyopneumoniae se encontró en la combinación más frecuente detectada en este estudio asociada con bacterias o agentes virales. (Texto tomado de la fuente)
dc.description.abstractPorcine Respiratory Complex (PRC) is a multifactorial and complex disease in growing and finishing pigs that causes major losses in the pig industry throughout the world. The goal of this study was to determine the different pneumonic patterns present by morphological studies and to establish their severity in finishing pigs belonging to a farm from the eastern part of Colombia. Samples from lungs and lymphatic nodules were collected from pigs at the abattoir plant. These lungs were examined by a external pathological professional to detect craneoventral Bronchopneumonia (BP) lesions. Out of 1000 pigs examined, only from 153 samples were collected. Fifty-two pigs were taken as control because they do not have gross lesions and one hundred one pigs were called cases because they had pneumonic craneoventral lesions. The histopathological lesions revealed in the control group the presence of Interstitial Pneumonia (IP) in 59.62% of the cases, and two combined pneumonic patterns in 19.23% of the cases (Broncho-Interstitial Pneumonia and Interstitial Pneumonia - BIP-IP). When the group of cases was studied, multiple pneumonic patterns were identified. The most frequent combination of microscopic pattern was suppurative bronchopneumonia (BP) and Broncho-Interstitial pneumonia (BIP) in 57.43% of the studied cases (BP-BIP), followed by the combination of three pneumonic patterns suppurative bronchopneumonia + broncho-interstitial pneumonia + interstitial pneumonia in 26.73% of the cases (BP-BIP-IP). These findings suggested that multiple interactions occurred among Porcine Respiratory Complex (PRC) pathogens and the varying severity among them. In addition, the lesions detected at the slaughter plant would be different if compared to the histopathological examination. Therefore, the histopathological studies offered a more accurate idea of the real lesions present when clinical pneumonia occurs. It may suggest that broncho-interstitial pneumonia compatible with M. hyopneumoniae were found in the more frequent combination detected in this study associated with bacteria or viral agents.
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Medicina Veterinaria y de Zootecnia - Especialidad en Anatomopatología Veterinaria
dc.publisherFacultad de Medicina Veterinaria y de Zootecnia
dc.publisherBogotá,Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
dc.relationBochsler PN. S DO. 2002. Inflammation and repair of tissue in mechanisms of disease. In: Do Hauson BJ C, editor. A textbook of comparative general pathology. 3rd ed. p. 140–245.
dc.relationBrockmeier SL, Halbur PG, Thacker EL. 2002. Porcine Respiratory Disease Complex. In: Brogden KA GJ, editor. Polymicrobial disease. Washington (DC): AMS Press. https://www.ncbi.nlm.nih.gov/books/NBK2481/.
dc.relationCaswell J, Williams K. 2016. Respiratory System. In: M. Grant Maxie, Jubb K& P, editor. Pathology of Domestic Animals. Sixth, Vol. p. 465–591.
dc.relatione Conti ER, Takeuti KL, Schwertz CI, Bianchi RM, Driemeier D, de Barcellos DESN. 2021. Agents of pneumonia in slaughtered pigs in southern Brazil. Pesqui Vet Bras. 41. doi:10.1590/1678-5150-PVB-6669.
dc.relationFablet C, Marois-Créhan C, Simon G, Grasland B, Jestin A, Kobisch M, Madec F, Rose N. 2012. Infectious agents associated with respiratory diseases in 125 farrow-to-finish pig herds: A cross-sectional study. Vet Microbiol. 157(1–2):152–163. doi:10.1016/j.vetmic.2011.12.015.
dc.relationGaldeano JVB, Baraldi TG, Ferraz MES, De Souza Almeida HM, Mechler-Dreibi ML, Costa WMT, Montassier HJ, Mathias LA, De Oliveira LG. 2019. Cross-sectional study of seropositivity, lung lesions and associated risk factors of the main pathogens of Porcine Respiratory Diseases Complex (PRDC) in Goiás, Brazil. Porc Heal Manag. 5(1):1–10. doi:10.1186/s40813-019-0130-0.
dc.relationGarcia-Morante B, Segalés J, Fraile L, Pérez de Rozas A, Maiti H, Coll T, Sibila M. 2016. Assessment of Mycoplasma hyopneumoniae-induced Pneumonia using Different Lung Lesion Scoring Systems: A Comparative Review. J Comp Pathol. 154(2–3):125–134. doi:10.1016/j.jcpa.2015.11.003.
dc.relationGoecke NB, Kobberø M, Kusk TK, Hjulsager CK, Pedersen KS, Kristensen CS, Larsen LE. 2020. Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing. Porc Heal Manag. 6(1):1–14. doi:10.1186/s40813-020-00161-3.
dc.relationHansen MS, Pors SE, Jensen HE, Bille-Hansen V, Bisgaard M, Flachs EM, Nielsen OL. 2010. An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. J Comp Pathol. 143(2–3):120–131. doi:10.1016/j.jcpa.2010.01.012. http://dx.doi.org/10.1016/j.jcpa.2010.01.012.
dc.relationHarms PA, Halbur PG, Sorden SD. 2002. Three cases of porcine respiratory disease complex associated with porcine circovirus type 2 infection. J Swine Heal Prod. 10(1):27–30.
dc.relationHernandez-Garcia J, Robben N, Magnée D, Eley T, Dennis I, Kayes SM, Thomson JR, Tucker AW. 2017. The use of oral fluids to monitor key pathogens in porcine respiratory disease complex. Porc Heal Manag. 3:1–13. doi:10.1186/s40813-017-0055-4.
dc.relationKekarainen T, Segalés J. 2015. Porcine circovirus 2 immunology and viral evolution. Porc Heal Manag. 1:4–9. doi:10.1186/s40813-015-0012-z. http://dx.doi.org/10.1186/s40813-015-0012-z.
dc.relationKrimmling T, Schwegmann-Weßels C. 2017. Comparison of mono- and co-infection by swine influenza A viruses and porcine respiratory coronavirus in porcine precision-cut lung slices. Res Vet Sci. 115(February):470–477. doi:http://dx.doi.org/10.1016/j.rvsc.2017.07.016.
dc.relationLopez A, Shannon M. 2022. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae. In: Zachary JF, editor. Pathologic Basis of Veterinary Disease. Seventh. Elsevier. p. 547–642.
dc.relationMaes D, Sibila M, Kuhnert P, Segalés J, Haesebrouck F, Pieters M. 2018. Update on Mycoplasma hyopneumoniae infections in pigs: Knowledge gaps for improved disease control. Transbound Emerg Dis. 65(March 2017):110–124. doi:10.1111/tbed.12677.
dc.relationMorrison RB, Hilley HD, Leman AD. 1985. Comparison of methods for assessing the prevalence and extent of pneumonia in market weight Swine. Can Vet J = La Rev Vet Can. 26(12):381–4.http://www.ncbi.nlm.nih.gov/pubmed/17422599%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC1680122.
dc.relationOpriessnig T, Giménez-Lirola LG, Halbur PG. 2011. Polymicrobial respiratory disease in pigs. Anim Health Res Rev. 12(2):133–148. doi:10.1017/s1466252311000120.
dc.relationOpriessnig T, Meng XJ, Halbur PG. 2007. Porcine circovirus type 2-associated disease: Update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J Vet Diagnostic Investig. 19(6):591–615. doi:10.1177/104063870701900601.
dc.relationOpriessnig T, Thacker EL, Yu S, Fenaux M, Meng XJ, Halbur PG. 2004. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Vet Pathol. 41(6):624–640. doi:10.1354/vp.41-6-624.
dc.relationOuyang T, Zhang X, Liu X, Ren L. 2019. Co-infection of swine with porcine circovirus type 2 and other swine viruses. Viruses. 11(2):16–20. doi:10.3390/v11020185.
dc.relationPaladino ES, Gabardo M de P, Lunardi PN, Morés N, Guedes RMC. 2017. Anatomopathological pneumonic aspects associated with highly pathogenic Pasteurella multocida in finishing pigs. Pesqui Vet Bras. 37(10):1091–1100. doi:10.1590/S0100-736X2017001000009.
dc.relationPallarés F, Añón J, Rodríguez-Gómez I, Gómez-Laguna J, Fabré R, Sánchez-Carvajal J, Ruedas-Torres I, Carrasco L. 2021. Prevalence of mycoplasma-like lung lesions in pigs from commercial farms from Spain and Portugal. Porc Heal Manag. 7(1):1–8. doi:10.1186/s40813-021-00204-3.
dc.relationPark SJ, Seo HW, Park C, Chae C. 2014. Interaction between single-dose Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus vaccines on dually infected pigs. Res Vet Sci. 96(3):516–522. doi:10.1016/j.rvsc.2014.03.009. http://dx.doi.org/10.1016/j.rvsc.2014.03.009.
dc.relationRoss FR. 1999. Mycoplasma Disease. In: Brabara E. Straw, Sylvie D’Allaire, William L. Mengeling DJT, editor. Disease of Swine. 8th ed. p. 495–509.
dc.relationRuggeri J, Salogni C, Giovannini S, Vitale N, Boniotti MB, Corradi A, Pozzi P, Pasquali P, Alborali GL. 2020. Association Between Infectious Agents and Lesions in Post-Weaned Piglets and Fattening Heavy Pigs With Porcine Respiratory Disease Complex (PRDC). Front Vet Sci. 7(September):1–11. doi:10.3389/fvets.2020.00636.
dc.relationSaade G, Deblanc C, Bougon J, Marois-Créhan C, Fablet C, Auray G, Belloc C, Leblanc-Maridor M, Gagnon CA, Zhu J, et al. 2020. Coinfections and their molecular consequences in the porcine respiratory tract. Vet Res. 51(1):1–19. doi:10.1186/s13567-020-00807-8. https://doi.org/10.1186/s13567-020-00807-8.
dc.relationSarli G, D’annunzio G, Gobbo F, Benazzi C, Ostanello F. 2021. The role of pathology in the diagnosis of swine respiratory disease. Vet Sci. 8(11). doi:10.3390/vetsci8110256.
dc.relationSarradell J, Andrada M, Ramírez AS, Fernández A, Gómez-Villamandos JC, Jover A, Lorenzo H, Herráez P, Rodríguez F. 2003. A morphologic and immunohistochemical study of the bronchus-associated lymphoid tissue of pigs naturally infected with Mycoplasma hyopneumoniae. Vet Pathol. 40(4):395–404. doi:10.1354/vp.40-4-395.
dc.relationSinha A, Shen HG, Schalk S, Beach NM, Huang YW, Meng XJ, Halbur PG, Opriessnig T. 2011. Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding. Vet Microbiol. 152(3–4):235–246. doi:10.1016/j.vetmic.2011.05.005. http://dx.doi.org/10.1016/j.vetmic.2011.05.005.
dc.relationThacker EL, Halbur PG, Ross RF, Thanawongnuwech R, Thacker BJ. 1999. Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia. J Clin Microbiol. 37(3):620–627. doi:10.1128/jcm.37.3.620-627.1999.
dc.relationVangroenweghe FACJ, Thas O. 2021. Seasonal variation in prevalence of mycoplasma hyopneumoniae and other respiratory pathogens in peri-weaned, post-weaned, and fattening pigs with clinical signs of respiratory diseases in belgian and dutch pig herds, using a tracheobronchial swab sampling. Pathogens. 10(9):1–14. doi:10.3390/pathogens10091202.
dc.relationWang X, Eaton M, Mayer M, Li H, He D, Nelson E, Christopher-Hennings J. 2007. Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability. Arch Virol. 152(2):289–303. doi:10.1007/s00705-006-0857-1.
dc.rightsAtribución-SinDerivadas 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEl diagnóstico histopatológico como un método de confirmación para la identificación de patrones de neumonía en cerdos de beneficio
dc.typeTrabajo de grado - Especialización


Este ítem pertenece a la siguiente institución