Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática

dc.contributorRey Buitrago, Mauricio
dc.contributorGenética clínica
dc.creatorRomero Fonseca, Adriana Zuleny
dc.date.accessioned2023-04-12T16:20:59Z
dc.date.available2023-04-12T16:20:59Z
dc.date.created2023-04-12T16:20:59Z
dc.date.issued2023-04-11
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/83699
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.description.abstractRevisión sistemática de la literatura donde se reporta el resultado de la búsqueda de variantes en genes del Sistema Antígeno Leucocitario Humano y TNF- α asociadas a los fenotipos periodontitis crónica y agresiva, y su posible desequilibrio de ligamiento. La periodontitis es una enfermedad infecciosa que afecta los tejidos de soporte del diente (hueso y encía), dentro de sus presentaciones más comunes se encuentran la periodontitis crónica y la periodontitis agresiva. El TNF-α es una citoquina involucrada en el desarrollo y progresión de la enfermedad periodontal tanto crónica como agresiva; el gen del TNF-α se encuentra dentro de los genes HLA III en el cromosoma 6, dichos genes son heredados en bloque junto con HLA I y HLA II (desequilibrio de ligamiento). Debido a su papel en el desarrollo de la enfermedad periodontal las variantes de TNF-α, HLA I y II pueden llegar a ser indicativos de susceptibilidad a padecer enfermedad periodontal. (Texto tomado de la fuente)
dc.description.abstractSystematic review of the literature where the results of the search for variants in genes of the Human Leukocyte Antigen System and TNF-α associated with the chronic and aggressive periodontitis phenotypes, and their possible linkage disequilibrium, are reported. Periodontitis is an infectious disease that affects the supporting tissues of the tooth (bone and gum), among its most common presentations are chronic periodontitis and aggressive periodontitis. TNF-α is a cytokine involved in the development and progression of both chronic and aggressive periodontal disease; the TNF-α gene is found within the HLA III genes on chromosome 6, these genes are inherited en bloc along with HLA I and HLA II (linkage disequilibrium). Due to their role in the development of periodontal disease, TNF-α, HLA I and II variants may become indicative of susceptibility to periodontal disease.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Medicina - Maestría en Inmunología
dc.publisherFacultad de Medicina
dc.publisherBogotá,Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleVariantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
dc.typeTrabajo de grado - Maestría


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