dc.creatorUniversidad San Sebastián
dc.creatorUniversidad San Sebastián
dc.creatorUniversidad San Sebastián
dc.creatorUniversidad San Sebastián
dc.creatorGrizzell, J. Alex
dc.creatorPatel, Sagar
dc.creatorBarreto, George E.
dc.creatorEcheverria, Valentina
dc.date.accessioned2023-05-24T04:45:13Z
dc.date.available2023-05-24T04:45:13Z
dc.date.created2023-05-24T04:45:13Z
dc.date.issued2017-08-01
dc.identifier0278-5846
dc.identifierhttps://repositorio.uss.cl/handle/uss/5848
dc.identifier10.1016/j.pnpbp.2017.05.010
dc.description.abstractAlzheimer's disease (AD) is associated with the progressive aggregation of hyperphosphorylated forms of the microtubule associated protein Tau in the central nervous system. Cotinine, the main metabolite of nicotine, reduced working memory deficits, synaptic loss, and amyloid β peptide aggregation into oligomers and plaques as well as inhibited the cerebral Tau kinase, glycogen synthase 3β (GSK3β) in the transgenic (Tg)6799 (5XFAD) mice. In this study, the effect of cotinine on visual recognition memory and cortical Tau phosphorylation at the GSK3β sites Serine (Ser)-396/Ser-404 and phospho-CREB were investigated in the Tg6799 and non-transgenic (NT) littermate mice. Tg mice showed short-term visual recognition memory impairment in the novel object recognition test, and higher levels of Tau phosphorylation when compared to NT mice. Cotinine significantly improved visual recognition memory performance increased CREB phosphorylation and reduced cortical Tau phosphorylation. Potential mechanisms underlying theses beneficial effects are discussed.
dc.languageeng
dc.relationProgress in Neuro-Psychopharmacology and Biological Psychiatry
dc.titleCotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice
dc.typeArtículo


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