How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study

dc.creatorCampodónico, Paola
dc.creatorTapia, Ricardo
dc.creatorSuárez, Cristian
dc.date.accessioned2022-03-10T13:55:45Z
dc.date.accessioned2023-05-19T14:53:05Z
dc.date.available2022-03-10T13:55:45Z
dc.date.available2023-05-19T14:53:05Z
dc.date.created2022-03-10T13:55:45Z
dc.date.issued2022
dc.identifierCampodónico PR, Tapia RA, Suárez-Rozas C. How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study. Front Chem. 2022 Feb 2;9:740161. doi: 0.3389/fchem.2021.740161
dc.identifierhttps://doi.org/10.3389/fchem.2021.740161
dc.identifierhttp://hdl.handle.net/11447/5686
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6303438
dc.description.abstractThe reactions between 2-chloro-5-nitro pyrimidine with a serie of α-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Brønsted type-plot, opening a controversial discussion based on reactivities and possible reaction pathways. These split Brønsted type-plots are discussed over the hypothetical transition state (TS) structures associated to concerted or stepwise mechanisms with emphasis on hydrogen bond interactions between electrophile/nucleophile pair able to determine the reactivities and the plausible reaction routes.
dc.languageen
dc.subjectSNAr reactions
dc.subjectbrønsted type-plots
dc.subjecthydrogen bond interaction
dc.subjectmechanisms
dc.subjectreactivity
dc.titleHow the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study
dc.typeArticle


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