Chile | Article
dc.creatorCruces, Pablo
dc.creatorRetamal, Jaime
dc.creatorHurtado, Daniel E.
dc.creatorErranz, Benjamín
dc.creatorIturrieta, Pablo
dc.creatorGonzález, Carlos
dc.creatorDíaz, Franco
dc.date.accessioned2021-11-02T15:25:01Z
dc.date.accessioned2023-05-19T14:45:48Z
dc.date.available2021-11-02T15:25:01Z
dc.date.available2023-05-19T14:45:48Z
dc.date.created2021-11-02T15:25:01Z
dc.date.issued2020
dc.identifierCritical Care (2020) 24:494
dc.identifierhttps://doi.org/10.1186/s13054-020-03197-7
dc.identifierhttp://hdl.handle.net/11447/4991
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6301384
dc.description.abstractDeterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view
dc.languageen_US
dc.subjectMechanical ventilation
dc.subjectSARS-CoV2
dc.subjectCOVID-19
dc.subjectP-SIL
dc.subjectLung strain
dc.subjectWork of breathing
dc.titleA physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
dc.typeArticle


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