dc.creator | Lowensteyn, Yvette N. | |
dc.creator | Nairb, Harish | |
dc.creator | Nunes, Marta C. | |
dc.creator | Roessel, Ichelle van | |
dc.creator | Vernooij, Femke S. | |
dc.creator | Willemsen, Joukje | |
dc.creator | Mazur, Natalie I. | |
dc.creator | Bont, Louis J. | |
dc.creator | FLU GOLD study group | |
dc.creator | Díaz, Franco | |
dc.date.accessioned | 2021-12-09T16:41:20Z | |
dc.date.accessioned | 2023-05-19T14:40:57Z | |
dc.date.available | 2021-12-09T16:41:20Z | |
dc.date.available | 2023-05-19T14:40:57Z | |
dc.date.created | 2021-12-09T16:41:20Z | |
dc.date.issued | 2021 | |
dc.identifier | Yvette N Löwensteyn, Harish Nair, Marta C Nunes, Ichelle van Roessel, Femke S Vernooij, Joukje Willemsen, Louis J Bont, Natalie I Mazur. Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series. In: EClinicalMedicine, Volume 37, 2021, 100945, https://doi.org/10.1016/j.eclinm.2021.100945. | |
dc.identifier | https://doi.org/10.1016/j.eclinm.2021.100945. | |
dc.identifier | http://hdl.handle.net/11447/5210 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/6300819 | |
dc.description.abstract | Background
Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months of age from influenza infection. However, it is unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified mortality data are lacking.
Methods
We invited clinicians and researchers to share clinical and demographic characteristics from children younger than 5 years who died with laboratory-confirmed influenza infection between January 1, 1995 and March 31, 2020. We evaluated the potential impact of maternal vaccination by estimating the number of children younger than 3 months with in-hospital influenza-related death using published global mortality estimates.
Findings
We included 314 children from 31 countries. Comorbidities were present in 166 (53%) children and 41 (13%) children were born prematurely. Median age at death was 8·6 (IQR 4·5–16·6), 11·5 (IQR 4·3–24·0), and 15·5 (IQR 7·4–27·0) months for children from low- and lower-middle-income countries (LMICs), upper-middle-income countries (UMICs), and high-income countries (HICs), respectively. The proportion of children younger than 3 months at time of death was 17% in LMICs, 12% in UMICs, and 7% in HICs. We estimated that 3339 annual influenza-related in-hospital deaths occur in the first 3 months of life globally.
Interpretation
In our study, less than 20% of children is younger than 3 months at time of influenza-related death. Although maternal influenza vaccination may impact maternal and infant influenza disease burden, additional immunisation strategies are needed to prevent global influenza-related childhood mortality. The missing data, global coverage, and data quality in this study should be taken into consideration for further interpretation of the results. | |
dc.language | en | |
dc.subject | Maternal vaccination | |
dc.subject | Impact | |
dc.subject | Paediatric influenza | |
dc.title | Estimated impact of maternal vaccination on global paediatric influenzarelated in-hospital mortality: A retrospective case series | |
dc.type | Article | |