Farmacogenómica de los anticoagulantes orales: la importancia de establecer algoritmos de dosificación en población chilena
Pharmacogenomics of vitamin K antagonists
| dc.creator | Guzmán Oyarzo, Neftalí | |
| dc.creator | Vega Sanhueza, Mario | |
| dc.creator | Reyes Cadagán, Franco | |
| dc.creator | Guzmán Oyarzo, Dina | |
| dc.creator | Andaur Rademacher, Marcela | |
| dc.creator | Boguen Ojeda, Rodrigo | |
| dc.creator | Letelier Arias, Pablo | |
| dc.date | 2023-03-01T20:42:03Z | |
| dc.date | 2023-03-01T20:42:03Z | |
| dc.date | 2020 | |
| dc.date.accessioned | 2023-05-09T22:03:17Z | |
| dc.date.available | 2023-05-09T22:03:17Z | |
| dc.identifier | Revista médica de Chile, Vol. 148, N° 9, 1307-1314, 2020 | |
| dc.identifier | 10.4067/S0034-98872020000901307 | |
| dc.identifier | https://repositoriodigital.uct.cl/handle/10925/5079 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/6295427 | |
| dc.description | There is an important interindividual variability in dose requirement for coumarinic anticoagulants, which could be explained by genetic and non-genetic factors. Among hereditary factors, there are gene polymorphisms that code the therapeutic target and the main enzyme responsible for their metabolism. However, there are other candidate genes that could modulate dose requirements. The is a paucity of pharmacogenomic platforms to determine dose requirements of coumarinics in the Chilean population. Therefore, algorithms considering different variables to adjust individual dosages are required. Herein, we analyze the available evidence about factors that can modify the effects of vitamin K antagonists and that should be incorporated to dosing algorithms | |
| dc.description | Este trabajo fue apoyado por proyecto FEQUIP2018- PL-06, de la Vicerrectoría de Investigación y Postgrado de la Universidad Católica de Temuco. La institución no tuvo influencia en la preparación, revisión o aprobación del manuscrito. Los autores declaran no tener conflictos de interés | |
| dc.format | application/pdf | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.rights | Todos los derechos reservados | |
| dc.source | Revista médica de Chile | |
| dc.subject | Pharmacogenomic variants | |
| dc.subject | Coumarins | |
| dc.subject | Anticoagulants | |
| dc.subject | Anticoagulantes | |
| dc.subject | Cumarina | |
| dc.subject | Farmacogenética | |
| dc.title | Farmacogenómica de los anticoagulantes orales: la importancia de establecer algoritmos de dosificación en población chilena | |
| dc.title | Pharmacogenomics of vitamin K antagonists | |
| dc.type | Artículo de Revista | |
| dc.coverage | Chile |