info:ar-repo/semantics/artículo
Human brucellosis and adverse pregnancy outcomes
Fecha
2016-12Autor
Arenas-Gamboa, Angela M.
Rossetti, Carlos Alberto
Chaki, Sankar P.
Garcia-Gonzalez, Daniel G.
Adams, Leslie G.
Ficht, Thomas A.
Resumen
Purpose of Review Brucellosis is a neglected, zoonotic disease
of nearly worldwide distribution. Despite brucellosis being
recognized as a reproductive disease in animals, it has
been historically known as a flu-like illness in humans with
little or no significant role in maternal or newborn health. This
review focuses on what is currently known relative to the
epidemiology of brucellosis in human pregnancy as well as
new insights of placental immunology.
Recent Findings New evidence suggests that maternal infection
poses a significant risk factor for adverse pregnancy outcomes
including increased risk for miscarriage during the first
and second trimester of gestation, preterm delivery, and vertical
transmission to the fetus. Adverse pregnancy outcomes
were not associated with any specific clinical sign. However,
prompt diagnosis and treatment significantly decreased the
risk of miscarriage or any other adverse effect.
Summary Brucellosis during pregnancy should be considered
a significant risk factor for adverse pregnancy outcomes in
humans. The identification of the mechanism behind bacterial
tropism should prove powerful for the development of new
countermeasures to prevent these detrimental effects.
Increased awareness concerning brucellosis in pregnant women,
its transmission, and prevention measures should be considered
as a pressing need.