artículo científico
Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300
Fecha
2012-10-08Registro en:
1521-3757
10.1002/ange.201206815
Autor
Majmudar, Chinmay Y.
Højfeldt, Jonas W.
Arevang, Carl J.
Pomerantz, William C.
Gagnon, Jessica K.
Schultz, Pamela J.
Cesa, Laura C.
Doss, Conor H.
Rowe, Steven P.
Vásquez Chaves, Víctor
Tamayo Castillo, Giselle
Cierpicki, Tomasz
Brooks, Charles L. III
Sherman, David H.
Mapp, Anna K.
Institución
Resumen
Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.