Genome sequencing variations in the Octodon degus, an unconventional natural model of aging and Alzheimer's disease

dc.creatorHurley, Michael J.
dc.creatorUrra, Claudio
dc.creatorGarduno, B. Maximiliano
dc.creatorBruno, Agostino
dc.creatorKimbell, Allison
dc.creatorWilkinson, Brent
dc.creatorMarino Buslje, Cristina
dc.creatorEzquer, Marcelo
dc.creatorEzquer, Fernando
dc.creatorAburto, Pedro F.
dc.creatorPoulin, Elie
dc.creatorVásquez, Rodrigo A.
dc.creatorDeacon, Robert
dc.creatorÁvila Macaya, Ariel
dc.creatorDeacon, Francisco
dc.creatorWhitney Vanderklish, Peter
dc.creatorZampieri, Guido
dc.creatorAngione, Claudio
dc.creatorConstantino, Gabriele
dc.creatorHolmes, Todd C.
dc.creatorCoba, Marcelo P.
dc.creatorXu, Xiangmin
dc.creatorCogram, Patricia
dc.date2022-10-17T17:12:29Z
dc.date2022-10-17T17:12:29Z
dc.date2022
dc.identifierHurley MJ, Urra C, Garduno BM, Bruno A, Kimbell A, Wilkinson B, et al. Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer’s Disease. Front. Aging Neurosci. 2022;14: Article 894994. Disponible en: https://doi.org/10.3389/fnagi.2022.894994
dc.identifier1663-4365
dc.identifierhttp://repositoriodigital.ucsc.cl/handle/25022009/3029
dc.descriptionArtículo de publicación WOS - SCOPUS
dc.descriptionThe degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E (Apoe) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.
dc.languageen
dc.publisherFrontiers
dc.subjectAlzheimer’s disease
dc.subjectAging
dc.subjectGenome
dc.subjectAPOE
dc.subjectAmyloids
dc.subjectLipid droplets
dc.subjectOctodon degus
dc.subjectdrug development
dc.titleGenome sequencing variations in the Octodon degus, an unconventional natural model of aging and Alzheimer's disease
dc.typeArticle


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