Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena

Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults

dc.creatorPetermann, Fanny
dc.creatorVillagrán, Marcelo
dc.creatorTroncoso Pantoja, Claudia
dc.creatorMardones Leiva, Lorena
dc.creatorLeiva, Ana María
dc.creatorMartínez, María Adela
dc.creatorGarrido Méndez, Alex
dc.creatorPoblete-Valderrama, Felipe
dc.creatorSalas-Bravo, Carlos
dc.creatorRamírez-Vélez, Robinson
dc.creatorUlloa, Natalia
dc.creatorPérez-Bravo, Francisco
dc.creatorCelis-Morales, Carlos
dc.date2020-06-03T18:07:51Z
dc.date2020-06-03T18:07:51Z
dc.date2018-06
dc.identifierRevista Médica de Chile, vol.146, no.6, June 2018, pp. 717-726
dc.identifier0034-9887
dc.identifierhttp://repositoriodigital.ucsc.cl/handle/25022009/1744
dc.descriptionArtículo de publicación ISI
dc.descriptionBackground: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
dc.languagees
dc.publisherSociedad Médica de Santiago
dc.sourcehttp://dx.doi.org/10.4067/s0034-98872018000600717
dc.subjectAdiposity
dc.subjectAlpha-Ketoglutarate-Dependent Dioxygenase FTO
dc.subjectGenotype
dc.subjectObesity
dc.titleAsociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
dc.titleAssociation between FTO (ns9939609) genotype and adiposity markers in Chilean adults
dc.typeArticle


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