Influence of trial registration on reporting quality of randomized trials: Study from highest ranked journals

dc.creatorReveiz, Ludovic
dc.creatorCortés Jofré, Marcela
dc.creatorAsenjo Lobos, Claudia
dc.creatorNicita, G.
dc.creatorCiapponi, A.
dc.creatorGarcıá-Dieguez, M.
dc.creatorTellez, D.
dc.creatorDelgado, M.
dc.creatorSolá, I.
dc.creatorOspina, E.
dc.date2015-12-02T19:43:57Z
dc.date2015-12-02T19:43:57Z
dc.date2010
dc.identifierJournal of Clinical Epidemiology, Volume 63, Issue 11, November 2010, Pages 1216-1222
dc.identifier0895-4356
dc.identifierhttp://repositoriodigital.ucsc.cl/handle/25022009/690
dc.identifier10.1016/j.jclinepi.2010.01.013
dc.descriptionArtículo de publicación ISI
dc.descriptionObjective: To evaluate the reporting quality of key methodological items of randomized control trials (RCTs) in 55 of the highest ranked journals. Study Design and Setting: A list of the highest top ranked journals was identified, and a search for detecting RCTs in those journals was made. Two hundred sixty four journals were screened and 55 of them were identified having at least one RCT. Three RCTs were randomly selected a priori from each journal; 148 RCTs were finally included. RCTs were assessed by two reviewers using the Consolidated Standards of Reporting Trials (CONSORT) statement. Results: Only 11 (8%) RCTs had all items adequately reported. In addition, 36% of RCTs reported that the study was registered in any trial registry. We found a significant difference in the quality of reporting for baseline characteristics, recruitment, participant’s flow, and randomization implementation between those studies having reported the registration of their RCT in a trial registry and those that have not. Adherence to key methodological items of the CONSORT statement was as follows: sample size determination (60%), sequence generation (49%), allocation concealment (40%), and blinding (25%). Conclusions: Reporting of varied CONSORT items remains suboptimal. Registration in a trial registry was associated with improved reporting. Further efforts to enhance RCT registration could contribute to this improvement.
dc.languageen
dc.publisherElsevier
dc.rightsAtribucion-Nocomercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourcehttps://doi.org/10.1016/j.jclinepi.2010.01.013
dc.subjectRandomized controlled trials
dc.subjectclinical trials
dc.subjecteditorial policies
dc.subjectquality control
dc.subjectbias
dc.subjectmethods
dc.titleInfluence of trial registration on reporting quality of randomized trials: Study from highest ranked journals
dc.typeArticle


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