The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter

dc.creatorMardones Leiva, Lorena
dc.creatorOrmazábal, Valeska
dc.creatorRomo, Ximena
dc.creatorJaña, Claudia
dc.creatorBinder, Pablo
dc.creatorPeña, Eduardo
dc.creatorVergara, Marilyn
dc.creatorZúñiga, Felipe
dc.date2015-11-23T18:25:30Z
dc.date2015-11-23T18:25:30Z
dc.date2011
dc.identifierBiochemical and Biophysical Research Communications 410
dc.identifier0006-291X
dc.identifierhttp://repositoriodigital.ucsc.cl/handle/25022009/428
dc.descriptionArtículo de publicación ISI
dc.descriptionWe studied the acquisition of dehydroascorbic acid by rat hepatocytes, H4IIE rat hepatoma cells and Xenopus laevis oocytes. Transport kinetics and competition and inhibition studies revealed that rat hepatocytes transport oxidized dehydroascorbic acid through a single functional component possessing the functional and kinetic properties expected for the glucose transporter GLUT2. On the other hand, rat hepatoma cells showed expression of at least two dehydroascorbic acid transporters with the expected functional and kinetic properties expected for GLUT1 and GLUT2. Expression studies of GLUT2 in X. laevis oocytes followed by transport kinetics and competition and inhibition studies revealed that GLUT2 is a low affinity dehydroascorbic transporter whose kinetic and functional properties match those observed for the endogenous GLUT2 transporter in rat hepatocytes and rat hepatoma cells. Therefore, GLUT2, a transporter known as a low affinity transporter of glucose and fructose and a high affinity transporter of glucosamine is also a low affinity dehydroascorbic acid transporter.
dc.languageen
dc.publisherResearchGate
dc.rightsAtribucion-Nocomercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourcehttp://goo.gl/9w04ZN
dc.subjectDehydroascorbic acid
dc.subjectVitamin C
dc.subjectGLUTs
dc.subjectSVCTs
dc.subjectHepatocytes
dc.subjectH4IIE cell
dc.titleThe glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter
dc.typeArticle


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