Artículos de revistas
SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil
Fecha
2022-01-01Registro en:
Revista do Instituto de Medicina Tropical de Sao Paulo, v. 64.
1678-9946
0036-4665
10.1590/S1678-9946202264003
2-s2.0-85124275676
Autor
Secretaria Municipal de Saúde
Universidade do Estado de São Paulo
Centro de Laboratório Regional Santo André
Centro de Virologia
Centro de Imunologia
Institución
Resumen
The COVID-19 pandemic in Brazil has been marked by high infection and death rates. The immune response generated by current vaccination might be influenced by previous natural infection, and baseline estimates may help in the evaluation of vaccine-induced serological response. We evaluated previous SARS-CoV-2 testing (RT-PCR), and performed rapid diagnostic tests (RDT) and high throughput electrochemiluminescence immunoassay (ECLIA) before vaccination among people living with HIV (PLWH), users of antiretroviral prophylaxis (PrEP/PEP), and healthcare professionals in an HIV outpatient clinic (HCP-HC). RDT was positive in 25.7% (95% CI: 19-33%) overall, 31.3% (95% CI: 18-45%) among PLWH, 23.7% (95% CI: 14-34%) in PrEP/PEP users and 21.4% (95% CI: 05-28%) in HCP-HC (p=0.548). Diagnostic RT-PCR testing was very limited, even for symptomatic individuals, and whereas all HCP-HC had one test perfomed, only 35% of the patients (PREP/ PEP/PLWH) were tested (p<0.0001). Adequate monitoring of post-vaccination humoral response and breakthrough infections including those in asymptomatic cases are warranted, especially in immunologically compromised individuals.