Artículos de revistas
Stability study of azithromycin in ophthalmic preparations
Fecha
2009-04-01Registro en:
Brazilian Journal of Pharmaceutical Sciences, v. 45, n. 2, p. 219-226, 2009.
1984-8250
2175-9790
10.1590/S1984-82502009000200005
2-s2.0-76149119801
Autor
Universidade de São Paulo (USP)
Institución
Resumen
A stability study of azithromycin in ophthalmic preparations was developed by submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3) for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 μ g/mL. The study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA).