Artículos de revistas
Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry
Date
2022-03-01Registration in:
International Journal of Infectious Diseases, v. 116, p. 319-327.
1878-3511
1201-9712
10.1016/j.ijid.2022.01.016
2-s2.0-85124200530
Author
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal do Rio Grande do Sul. Coordinator of the Institute for Health Technology Assessment (IATS/CNPq). Rua Ramiro Barcelos
Physician. Hospital Unimed-BH
Hospitais da Rede Mater Dei
01
Physician. Hospital Santa Rosália
400
Universidade Estadual Paulista (UNESP)
Hospital de Clínicas de Porto Alegre
Hospital Mãe de Deus
Hospital Santo Antônio
Pharmaceutical. Hospital de Clínicas de Porto Alegre
Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor
Hospital SOS Cárdio
Nephrologist. Hospital Universitário Ciências Médicas
Hospital Márcio Cunha
Hospital Regional do Oeste
Brasil. Hospital São Lucas PUCRS
Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)
Undergraduate Medical Student. Universidade Federal dos Vales do Jequitinhonha e Mucuri. R. Cruzeiro 1
Hospital Luxemburgo
Hospital Nossa Senhora da Conceição
Hospital Bruno Born
Hospital Moinhos de Vento
Hospital Metropolitano Odilon Behrens
Hospital Santa Cruz
Hospital Julia Kubitschek. Avenida Professor Alfredo Balena 190
Hospital São Lucas PUCRS
2213
311
Hospital São João de Deus
389
Hospital Universitário Canoas
Hospital Universitário de Santa Maria
Hospital Tacchini
Researcher. Institute for Health Technology Assessment (IATS/ CNPq). Rua Ramiro Barcelos
Institutions
Abstract
Background: It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. Methods: The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis. Results: Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062). Conclusion: Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.