Artículos de revistas
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study
Fecha
2010-12-01Registro en:
Clinical and Experimental Rheumatology, v. 28, n. 4, p. 454-461, 2010.
0392-856X
1593-098X
2-s2.0-79952056556
Autor
University of California Los Angeles
University of California Berkeley
North Karelia Central Hospital
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
Universidade Federal do Ceará
Universidade Estadual Paulista (UNESP)
Hospital Universitário de Brasília
University of Ioannina Ioannina
Waterford Regional Hospital
Connolly Hospital
University of Genova
Rheumatology Department
Vilnius University
University Medical Centre Utrecht
Jyväskylä Central Hospital
Medcare Oy
Hospital Oakland Research Institute
Hospital San Juan Bautista
Hospital of Cordoba
Universidade do Estado do Rio de Janeiro (UERJ)
Riverside Professional Centre
Copenhagen University Hospital at Hvidovre
King Christian the Xth Hospital
Copenhagen University Hospital at Herlev
Al-Azhar University
Assiut University Hospital
Abo Sohage University Hospital
Tartu University Hospital
East-Tallinn Central Hospital
Centre for Clinical and Basic Research
Satakunta Central Hospital
Hôpital Cochin
INSERM U887
Hôpital Lapeyronie
Hôpital Hautepierre
National University of Athens
Euroclinic Hospital
Evangelisches Fachkrankenhaus
Schlosspark-Klinik
University Medicine Berlin
Semmelweis University of Medical Sciences
Polyclinic of the Hospitaller Brothers of St. John of God in Budapest
St. Vincent University Hospital
Our Lady's Hospice
Vedanta Institiute of Medical Sciences
Jaipur Hospital
Santa Chiara Hospital
Catholic University of Sacred Heart
University of Ancona
Tokyo Women's Medical University
Kyoto First Red Cross Hospital
Shono Rheumatism Clinic
Kenyatta Hospital
Pauls Stradina Clinical University Hospital
Kaunas University Hospital
El Ayachi Hospital Mohamed Vth Souissi University
Sint Franciscus Gasthuis Hospital
Medisch Spectrum Twente
Sørlandet Hospital
Medical University in Bialystok
Medical University of Lublin
Poznan Rheumatology Centre in Srem
Military Institute of Medicine
Silesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski
Szpital Wojewodzki im. Jana Biziela
Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko
Spitalul Clinic Sf Maria
Institute of Rheumatology of Russian Academy of Medical Sciences
Moscow Medical Academy
Russian Medical Academy of Postgraduate Education
Rheumatology Institut
Hospital de Gran Canaria Dr. Negrin
Hospital Sierrallana Ganzo
Hospital General de Castellón
Uppsala University Hospital
Centrallasarettet
Hudiksvall Medical Clinic
Gazi University Medical Faculty
Meram Medical Faculty
Cerrahpasa Medic Faculty
Dubai Bone and Joint Centre
American Hospital Dubai
Charing Cross Hospital
Royal Cornwall Hospital
Kings College Hospital
Vanderbilt University
NYU Hospital for Joint Diseases
Taylor Hospital
Centra Care Clinic
University of Arkansas for Medical Sciences
New York University Hospital for Joint Diseases
Institución
Resumen
Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men. © Copyright Clinical and Experimental Rheumatology 2010.