Calcium-independent membrane damage by venom phospholipases A2

Artículos de revistas

Fecha

2009-01-01

Registro en:

Protein and Peptide Letters, v. 16, n. 8, p. 877-886, 2009.

0929-8665

http://hdl.handle.net/11449/219518

10.2174/092986609788923392

2-s2.0-68849106813

https://repositorioslatinoamericanos.uchile.cl/handle/2250/5399647

Autor

Universidade de São Paulo (USP)

Universidade Estadual Paulista (UNESP)

Institución

Universidade Estadual Paulista (Brasil)

Resumen

Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA 2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins. © 2009 Bentham Science Publishers Ltd.

Materias

Membrane permeabilization

Micelle nucleation

Molecular mechanism

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