Artículos de revistas
HLA-E gene polymorphisms in chronic hepatitis C: Impact on HLA-E liver expression and disease severity
Fecha
2021-03-01Registro en:
Human Immunology. New York: Elsevier Science Inc, v. 82, n. 3, p. 177-185, 2021.
0198-8859
10.1016/j.humimm.2021.01.018
WOS:000621423600006
Autor
Universidade de São Paulo (USP)
Univ Toronto Mississauga
Hosp Israelita Albert Einstein
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Hepatitis C virus usually produces chronic infection and liver damage. Considering that: i) the human leukocyte antigen-E (HLA-E) molecule may modulate the immune response, and ii) little is known about the role of HLA-E gene variability on chronic hepatitis C, we studied the impact of HLA-E polymorphisms on the magnitude of HLA-E liver expression and severity of hepatitis C. HLA-E variability was evaluated in terms of: i) single nucleotide polymorphism (SNP) alleles and genotypes along the gene (beginning of the promoter region, coding region and 30UTR), and ii) ensemble of SNPs that defines the coding region alleles, considered individually or as genotypes. The comparisons of the HLA-E variation sites between patients and controls revealed no significant results. The HLA-E + 424 T > C (rs1059510), +756 G > A (rs1264457) and + 3777 G > A (rs1059655) variation sites and the HLA-E*01:01:01:01 and HLAE*01:03:02:01 alleles, considered at single or double doses, were associated with the magnitude of HLA-E liver expression in Kupfer cell, steatosis, inflammatory activity and liver fibrosis. Although these associations were lost after corrections for multiple comparisons, these variable sites may propitiate biological clues for the understanding of the mechanisms associated with hepatitis C severity. (C) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.