Artículos de revistas
A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas
Fecha
2020-04-01Registro en:
Pituitary, v. 23, n. 2, p. 120-128, 2020.
1573-7403
1386-341X
10.1007/s11102-019-01008-z
2-s2.0-85075050448
Autor
Universidade de São Paulo (USP)
Federal University of Rio de Janeiro
Universidade Federal de Pernambuco (UFPE)
Federal University of Ceara
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Federal University of Parana
Irmandade da Santa Casa de Misericórdia de São Paulo
Hospital de Clinicas de Porto Alegre (UFRGS)
Institute of Medical Assistance to the State Public Hospital
Universidade Estadual Paulista (Unesp)
Universidade Federal de Minas Gerais (UFMG)
Institución
Resumen
Objective: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods: The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results: We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions: Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.