Artículos de revistas
Sliding mode control in a mathematical model to chemoimmunotherapy: The occurrence of typical singularities
Fecha
2020-12-15Registro en:
Applied Mathematics and Computation, v. 387.
0096-3003
10.1016/j.amc.2019.124782
2-s2.0-85073559844
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Institución
Resumen
The application of sliding mode control and piecewise smooth vector fields in cancer is an incipient research area. Here we propose a piecewise dynamics to explore chemoimmunotherapeutic strategies. We investigate the dynamic behavior of the discontinuous mathematical model and we observe the occurrence of typical singularities. The on-off treatment strategies are defined in terms of a time-dependent variable such as the number of cancer or immune cells.