Artículos de revistas
Collaborative Brazilian pediatric renal transplant registry (CoBrazPed-RTx): A report from 2004 to 2018
Fecha
2019-01-01Registro en:
Pediatric Transplantation, v. 23, n. 6, 2019.
1399-3046
1397-3142
10.1111/petr.13463
2-s2.0-85069872983
Autor
Universidade de Caxias do Sul/Hospital Geral de Caxias do Sul
Universidade Federal Ciencias da Saude de Porto Alegre
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Ciências da Saúde de Porto Alegre
Hospital Samaritano
Hospital Geral de Fortaleza
Universidade de São Paulo (USP)
Curitiba
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
Santa Casa de São Paulo
Hospital de Base
Instituto Urologia e Nefrologia
Universidade Federal de Minas Gerais (UFMG)
Hospital Ana Nery
Santa Casa de Belo Horizonte
Programa de Pós-Graduação em Saúde da Criança e do Adolescente- Universidade Federal do Rio Grande do Sul
Institución
Resumen
The Brazilian collaborative registry for pediatric renal transplantation began in 2004 as a multicenter initiative aimed at analyzing, reporting, and disseminating the results of pediatric renal transplantation in Brazil. Data from all pediatric renal transplants performed from January 2004 to May 2018 at the 13 participating centers were analyzed. A total of 2744 pediatric renal transplants were performed in the thirteen participating centers. The median age at transplantation was 12.2 years, with the majority being male recipients (56%). The main underlying diseases were CAKUT (40.5%) and glomerulopathy (28%). 1981 (72%) of the grafts were from deceased donors (DD). Graft survival at one year (censored by death) was 94% in the live donor group (LD) and 91% in the DD group (log-rank test P < 0.01). The patient’s survival at one and 5 years was 97% and 95% for the LD group and 96% and 93% for the DD group (log-rank test P = 0.02). The graft loss rate was 19% (n = 517), more frequently caused by vascular thrombosis (n = 102) and chronic graft nephropathy (n = 90). DD recipients had 1.6 (1.0-2.2) times greater chance of death and 1.5 (1.2-1.8) times greater chance of graft loss compared to LD recipients. The mortality rate was 5.4% (n = 148), mainly due to infection (n = 69) and cardiovascular disease (n = 28). The results of this collaborative pediatric renal transplant record are comparable to other international registries, although we still have a high infection rate as a cause of death.