Artículos de revistas
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms
Fecha
2019-03-01Registro en:
Basic and Clinical Pharmacology and Toxicology, v. 124, n. 3, p. 266-272, 2019.
1742-7843
1742-7835
10.1111/bcpt.13126
2-s2.0-85054709123
1525665408900195
0000-0001-7831-1149
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Universidade Federal da Bahia (UFBA)
Américo Brasiliense State Hospital (HEAB)
Institución
Resumen
Gabapentin (GAB) is eliminated unchanged in urine, and organic cation transporters (OCT2 and OCTN1) have been shown to play a role in GAB renal excretion. This prospective clinical study aimed to evaluate the genetic polymorphisms effect on GAB pharmacokinetic (PK) variability using a population pharmacokinetic approach. Data were collected from 53 patients with chronic pain receiving multiple doses of GAB. Patients were genotyped for SLC22A2 c.808G>T and SLC22A4 c.1507C>T polymorphisms. Both polymorphisms' distribution followed the Hardy-Weinberg equilibrium. An one-compartment model with first-order absorption and linear elimination best described the data. The absorption rate constant, volume of distribution, and clearance estimated were 0.44 h −1 , 86 L, and 17.3 × (estimated glomerular filtration ratio/89.58) 1.04 L/h, respectively. The genetic polymorphism SLC22A4 c.1507C>T did not have a significant influence on GAB absorption, distribution or elimination. Due to the low minor allelic frequency of SLC22A2 c.808G>T, further studies require higher number of participants to confirm its effect on GAB renal elimination. In conclusion, GAB clinical pharmacokinetics are strongly influenced by renal function and absorption process, but not by the OCTN1 (SLC22A4 c.1507C>T) polymorphism.