Artículos de revistas
Histopathological features of juvenile-onset laryngeal papillomatosis related to severity
Fecha
2019-05-01Registro en:
Head and Neck, v. 41, n. 5, p. 1412-1417, 2019.
1097-0347
1043-3074
10.1002/hed.25602
2-s2.0-85059661809
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Oral and Maxillofacial Pathologist at Centro Clínico de Cabeza y Cuello
São Paulo Federal University
Institución
Resumen
Background: Laryngeal papillomatosis (LP) is a disease that presents in both juvenile (JLP) and adult patients (ALP). This study correlated papillomatosis characteristics with the Derkay score. Methods: Retrospective data and biopsies of 36 patients with JLP and 56 with ALP were collected and separated into groups according to their scores. Results: The mean of the Derkay score, in the JLP group was 10.97 and in Group ALP was 8.26. The JLP group presented a more aggressive result than in the adult group (P =.02). In the JLP group, the respiratory difficulty (P =.01) and tracheostomy were correlated to a higher Derkay score (P <.05). Microscopically, the JLP samples presented a higher incidence of atypical mitosis and mitosis above the basal cells layer of the epithelium (P <.05) and these characteristics were correlated with a higher Derkay index (P =.03). Conclusion: Findings suggest that ALP and JLP can present different clinical courses and histopathological features. There was a higher degree of LP severity in JLP.