Artículos de revistas
Kaurenoic acid and its sodium salt derivative: Antibacterial activity against Porphyromonas gingivalis and their mechanism of action
Fecha
2018-11-01Registro en:
Future Microbiology, v. 13, n. 14, p. 1585-1601, 2018.
1746-0921
1746-0913
10.2217/fmb-2018-0140
2-s2.0-85056715505
Autor
University of Franca - UNIFRAN
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Aim: To evaluate the antibacterial activity of 12 kaurane-type diterpenes against a panel of bacteria that cause endodontic infection. Methods & materials: We conducted tests against bacteria in the planktonic or in the sessile mode, cytotoxic assays for the most promising compounds against human normal lung fibroblast cells, and Porphyromonas gingivalis (ATCC 33277) proteomic analysis. Results & conclusion: Kaurenoic acid and its salt exhibited satisfactory antibacterial action against the evaluated bacteria. Proteomic analysis suggested that these compounds might interfere in bacterial metabolism and virulence factor expression. Kaurane-type diterpenes are an important class of natural products and should be considered in the search for new irrigating solutions to treat endodontic infections.