Artículos de revistas
Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63
Fecha
2019-08-01Registro en:
Phytochemistry Letters. Amsterdam: Elsevier, v. 32, p. 162-167, 2019.
1874-3900
10.1016/j.phytol.2019.06.003
WOS:000476725000031
Autor
Universidade de São Paulo (USP)
Universidade Federal de Mato Grosso do Sul (UFMS)
Inst Fed Mato Grosso
Universidade Estadual Paulista (Unesp)
Universidade Federal de São Carlos (UFSCar)
Universidade Estadual de Campinas (UNICAMP)
Univ Sao Francisco
Universidade Federal de São Paulo (UNIFESP)
Institución
Resumen
Prenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological activities. Investigation of the growth medium EtOAc extract produced by the endophytic fungus Aspergillus terreus P63 collected from roots of the grass Axonopus leptostachyus, yielded the prenylated indole alkaloid, giluterrin, bearing an unprecedented carbon skeleton. The structure of giluterrin was established by analysis of spectroscopic data and HRMS. The absolute configuration of giluterrin was determined by combination of electronic and vibrational circular dichroism analyses. Giluterrin presented antiproliferative profile for prostate (PC-3) and kidney (786-0) cancer cell lines.