info:eu-repo/semantics/other.generacióndecontenidos
Lipopolysaccharides isolated from Eikenella corrodens but not from Porphyromonas gingivalis W83 induce proatherosclerotic inflammatory responses in human coronary artery endothelial cells
Autor
Gualtero Escobar, Diego Fernando
Bernau Gutiérrez, Sebastián
Viafara, Sergio
Buitrago Ramírez, Diana Marcela
Fontanilla Duque, Martha Raquel
Lafaurie Villamil, Gloria Inés
Resumen
Eikenella corrodens and Porphyromonas gingivalis are oral microorganisms associated with the periodontal disease and have been identified in atherosclerotic lesions. The pro-atherosclerotic potential of a periodontopathic species depends on the ability of the strain to infect the endothelium. Lipopolysaccharide (LPS) from atherosclerosis-associated bacteria causes innate inflammatory responses in the pathogenic processes induced by microorganisms. The purpose of this study was to compare the pro-inflammatory responses of human coronary artery endothelial cells (HCAECs) to LPS isolated from E. corrodens 23834 and P. gingivalis W83. Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias 1308-519-28960 Inducción de disfunción endotelial in vitro por lipopolisacarido de bacterias periodontopaticas e inhibición de la inflamación por resolvina (rvd1) y estatina (rosuvastatina) no