specializationThesis
Estudo de estabilidade da solução padrão de ibuprofeno no controle de qualidade por HPLC
Fecha
2019-05Registro en:
BRESCOVIT, Natali Silveira. Estudo de estabilidade da solução padrão de ibuprofeno no controle de qualidade por HPLC. 2019. Trabalho de Conclusão de Curso (Especialização em Análise Instrumental) – Universidade Tecnológica Federal do Paraná, Toledo, 2019.
Autor
Brescovit, Natali Silveira
Resumen
In this work, it was proposed to evaluate three different conditions of storage of the standard ibuprofen solution, in order to verify in which condition it would be possible to maintain its stability for a longer time, where the evaluation was done through the high performance liquid chromatography technique ( CLAE). The first condition assessed was storage of standard solution samples at room temperature, this condition presented satisfactory results, maintaining the stability of the standard for approximately 20h after its preparation. The second condition evaluated was the storage of samples in a refrigerator (2 ° C to 8 ° C), where unsatisfactory results were obtained, since it recovered only after 8h its preparation. Subsequently, the third condition was evaluated where samples were stored in a greenhouse (30 ° C) and unsatisfactory results were obtained, where no recovery was obtained in any of the injections performed after 8h after preparation. Through these results it was possible to affirm that the packing of samples in greenhouse is better when compared with the other conditions.