bachelorThesis
Estudo de membranas à base de acetato de celulose com morfologia controlada para liberação de anti-inflamatórios
Fecha
2016-11-22Registro en:
SILVA, Leandro de Oliveira. Estudo de membranas à base de acetato de celulose com morfologia controlada para liberação de anti-inflamatórios. 2016. Trabalho de Conclusão de Curso (Licenciatura em Química) - Universidade Tecnológica Federal do Paraná, Campo Mourão, 2016.
Autor
Silva, Leandro de Oliveira
Resumen
The selection of polymers to compose a controlled release system should take into account the type of release and the type of drug. Regarding transdermal drug delivery, the polymer selected should also have certain permeability so that the enclosed drug can readily migrate from the delivery system to the skin. Among the release systems studied, membranes can be a viable alternative once they are semipermeable barriers, where the release or retention of drugs depends mainly on the size of the membrane pores and the size of the drug molecule. Within the presented context, the aim of this study was to investigate the influence of the cellulose acetate (CA) membrane morphology on the release of acetylsalicylic acid (ASA) and Paracetamol (PCT). CA membranes were prepared by the casting method using acetone, dichloromethane and solvent mixtures (acetone / water and dichloromethane / water) as solvent. The release of the active principle from different membranes was carried out in a solution with pH 6.8; 8.0 and 2.0 under constant stirring at 37 ° C. Aliquots were collected at specific time intervals, and absorption readings were performed on an UV-Vis spectrophotometer.For the membranes prepared with the solvent mixtures, a more accentuated release was noticed in the first minutes when compared to the membranes prepared with the pure solventes. These matrices showed a maximum release in approximately 36 hours, a relatively long time when compared to the conventional release method.It is possible to observe that, for CA membranes prepared with solvent mixture, the drug release occurs more strongly at the beginning, this can be justified by the degree of porosity observed in these membranes, which facilitates the permeation of the active principle. It is concluded that CA membranes have the potential to be used as controlled drug delivery systems, which justifies the continuity of this study so the effectiveness in vivo can be verified.