Open Educational Resource is any educational resources that are openly available for use by educators and students, without an accompanying need to pay royalties or license fees. There is a potential in the OER to change the educational reality. Some of the classic features about teaching and learning can change with the OER movement and some examples are teacher and student roles; reduction of the importance of the textbook with restricted rights to use; adoption of Open Education Practices (OEP). However, three challenges appear: get open educational resources on Biotechnology, choose the educational resources and plan its use in teaching and learning processes. The objectives of this paper are to present a survey of open educational resources on biotechnology and discuss aspects to guide the assessment of its quality.