Discovery of novel TASK-3 channel blockers using a pharmacophore-based virtual screening

dc.creatorRamírez D.
dc.creatorConcha G.
dc.creatorArévalo B.
dc.creatorPrent-Peñaloza L.
dc.creatorZúñiga L.
dc.creatorKiper A.K.
dc.creatorRinné S.
dc.creatorReyes-Parada M.
dc.creatorDecher N.
dc.creatorGonzález W.
dc.creatorCaballero J.
dc.date.accessioned2020-09-02T22:26:32Z
dc.date.accessioned2022-11-08T20:27:45Z
dc.date.available2020-09-02T22:26:32Z
dc.date.available2022-11-08T20:27:45Z
dc.date.created2020-09-02T22:26:32Z
dc.date.issued2019
dc.identifier20, 16, -
dc.identifier16616596
dc.identifierhttps://hdl.handle.net/20.500.12728/5950
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5146561
dc.languageen
dc.publisherMDPI AG
dc.subjectDrug design
dc.subjectLead optimization
dc.subjectPharmacophore-based virtual screening
dc.subjectTASK channels blockers
dc.subjectTASK-3 channel
dc.subjectpotassium channel blocking agent
dc.subjectKCNK9 protein, human
dc.subjectpotassium channel blocking agent
dc.subjecttandem pore domain potassium channel
dc.subjectArticle
dc.subjectbinding site
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcontrolled study
dc.subjectcrystal structure
dc.subjectFourier transform infrared spectroscopy
dc.subjecthigh throughput screening
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthydrogen bond
dc.subjectmass spectrometry
dc.subjectmolecular docking
dc.subjectmolecular dynamics
dc.subjectpatch clamp technique
dc.subjectpharmacophore
dc.subjectprotein conformation
dc.subjectprotein expression
dc.subjectproton nuclear magnetic resonance
dc.subjectstereochemistry
dc.subjectdrug design
dc.subjectHEK293 cell line
dc.subjectmolecular docking
dc.subjectDrug Design
dc.subjectHEK293 Cells
dc.subjectHumans
dc.subjectMolecular Docking Simulation
dc.subjectPotassium Channel Blockers
dc.subjectPotassium Channels, Tandem Pore Domain
dc.titleDiscovery of novel TASK-3 channel blockers using a pharmacophore-based virtual screening
dc.typeArticle


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