Targeting α -(1,4)-glucosidase in diabetes mellitus type 2: The role of new synthetic coumarins as potent inhibitors

dc.creatorFigueroa-Benavides C.
dc.creatorMatos M.J.
dc.creatorPeñaloza-Amion M.
dc.creatorVeas R.
dc.creatorValenzuela-Barra G.
dc.creatorZapata G.
dc.creatorDelogu G.
dc.creatorUriarte E.
dc.creatorSantana L.
dc.creatorOlea-Azar C.
dc.creatorDelporte C.
dc.date.accessioned2020-09-02T22:18:16Z
dc.date.accessioned2022-11-08T20:26:43Z
dc.date.available2020-09-02T22:18:16Z
dc.date.available2022-11-08T20:26:43Z
dc.date.created2020-09-02T22:18:16Z
dc.date.issued2018
dc.identifier18, 27, 2327-2337
dc.identifier15680266
dc.identifierhttps://hdl.handle.net/20.500.12728/4559
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5146160
dc.languageen
dc.publisherBentham Science Publishers B.V.
dc.subjectCoumarins
dc.subjectDiabetes mellitus
dc.subjectDmt2
dc.subjectDocking studies
dc.subjectMedicinal chemistry
dc.subjectΑ-(1,4)-glucosidase inhibition
dc.subject3 (4 bromothiophen 2 yl) 6 hydroxycoumarin
dc.subject3 (4 bromothiophen 2 yl) coumarin
dc.subject4 chloro n (7 hydroxy 4 methoxycoumarin 8 yl)benzamide
dc.subjectacarbose
dc.subjectalpha (1,4) glucosidase
dc.subjectalpha glucosidase
dc.subjectalpha glucosidase inhibitor
dc.subjectantidiabetic agent
dc.subjectcoumarin derivative
dc.subjecthydrogen
dc.subjectn (4 hydroxycoumarin 3 yl) 4 methoxybenzamide
dc.subjectn (4 hydroxycoumarin 3 yl)acetamide
dc.subjectn (7 hydroxy 4 methylcoumarin 8 yl) 4 nitrobenzamide
dc.subjectn (7 hydroxy 4 methylcoumarin 8 yl) nicotinamide
dc.subjectn (7 hydroxy 4 methylcoumarin 8 yl)benzamide
dc.subjectphenylalanine
dc.subjectSaccharomyces cerevisiae protein
dc.subjectunclassified drug
dc.subjectcoumarin derivative
dc.subjectglucan 1,4 alpha glucosidase
dc.subjectglycosidase inhibitor
dc.subjectArticle
dc.subjectchemical interaction
dc.subjectcontrolled study
dc.subjectdrug potency
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectdrug targeting
dc.subjectenzyme active site
dc.subjectenzyme inhibition
dc.subjecthydrogen bond
dc.subjecthydrophobicity
dc.subjectin vitro study
dc.subjectmolecular docking
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectSaccharomyces cerevisiae
dc.subjectantagonists and inhibitors
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectdose response
dc.subjectenzymology
dc.subjecthuman
dc.subjectmetabolism
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectstructure activity relation
dc.subjectCoumarins
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDose-Response Relationship, Drug
dc.subjectGlucan 1,4-alpha-Glucosidase
dc.subjectGlycoside Hydrolase Inhibitors
dc.subjectHumans
dc.subjectMolecular Structure
dc.subjectStructure-Activity Relationship
dc.titleTargeting α -(1,4)-glucosidase in diabetes mellitus type 2: The role of new synthetic coumarins as potent inhibitors
dc.typeArticle


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