Chile | Article

PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor

dc.creatorFernandes C.
dc.creatorMartins C.
dc.creatorFonseca A.
dc.creatorNunes R.
dc.creatorMatos M.J.
dc.creatorSilva R.
dc.creatorGarrido J.
dc.creatorSarmento B.
dc.creatorRemião F.
dc.creatorOtero-Espinar F.J.
dc.creatorUriarte E.
dc.creatorBorges F.
dc.date.accessioned2020-09-02T22:17:26Z
dc.date.accessioned2022-11-08T20:22:37Z
dc.date.available2020-09-02T22:17:26Z
dc.date.available2022-11-08T20:22:37Z
dc.date.created2020-09-02T22:17:26Z
dc.date.issued2018
dc.identifier10, 46, 39557-39569
dc.identifier19448244
dc.identifierhttps://hdl.handle.net/20.500.12728/4435
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5144494
dc.languageen
dc.publisherAmerican Chemical Society
dc.subjectcytotoxicity
dc.subjectdrug release
dc.subjectefflux transporters
dc.subjectintestinal and brain permeability
dc.subjectMAO-B inhibitors
dc.subjectP-glycoprotein
dc.subjectParkinson's disease
dc.subjectpolymeric nanosystems
dc.subjectAssays
dc.subjectCell culture
dc.subjectClinical research
dc.subjectControlled drug delivery
dc.subjectCytotoxicity
dc.subjectDrug products
dc.subjectEndothelial cells
dc.subjectGlycoproteins
dc.subjectNanoparticles
dc.subjectBlood-brain barrier
dc.subjectDrug release
dc.subjectEfflux transporter
dc.subjectMonoamine oxidase B
dc.subjectNanoprecipitation method
dc.subjectP-glycoprotein
dc.subjectParkinson's disease
dc.subjectPharmacokinetic properties
dc.subjectTargeted drug delivery
dc.subjectamine oxidase (flavin containing)
dc.subjectcoumarin
dc.subjectcoumarin derivative
dc.subjectdrug carrier
dc.subjectmonoamine oxidase inhibitor
dc.subjectnanoparticle
dc.subjectsurfactant
dc.subjectCaco-2 cell line
dc.subjectchemistry
dc.subjecthuman
dc.subjectIC50
dc.subjectParkinson disease
dc.subjectpermeability
dc.subjectscanning electron microscopy
dc.subjecttumor cell line
dc.subjectCaco-2 Cells
dc.subjectCell Line, Tumor
dc.subjectCoumarins
dc.subjectDrug Carriers
dc.subjectHumans
dc.subjectInhibitory Concentration 50
dc.subjectMicroscopy, Electron, Scanning
dc.subjectMonoamine Oxidase
dc.subjectMonoamine Oxidase Inhibitors
dc.subjectNanoparticles
dc.subjectParkinson Disease
dc.subjectPermeability
dc.subjectPolylactic Acid-Polyglycolic Acid Copolymer
dc.subjectSurface-Active Agents
dc.titlePEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor
dc.typeArticle


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