info:eu-repo/semantics/article
Clinical Features of Rotavirus Gastroenteritis and Their Association With Different Electropherotypes
Características clínicas de la gastroenteritis por rotavirus y su asociación con distintos electroferotipos
Autor
Sulbarán, María Z
Maldonado, Antonio J
Rojas, Yacqueline
Bastardo, Jesús W
Institución
Resumen
From June 1993 to June 1995 stool samples were obtained from 377 children with acute diarrhea admitted to the Antonio Patricio de Alcalá Hospital in Cumaná, Venezuela. Electrophoretic patterns of rotaviruses were detected in 27.85 per cent (105/377) of fecal samples. The long pattern (80%) prevailed over the short pattern (18.09%) and 2 specimens (1.91%) exhibited mixtures of electropherotypes. Viral RNA coelectrophoresis showed 6 distinct patterns, 4 electropherotypes of long profiles and 2 of short profiles. Association was found among the distinct electropherotypes detected and the clinical features of the illness. It was observed that the duration of diarrhea ranged from 3 to 6 days (73.8%), minimum daily evacuation was 1 to 2 times (85.4%), maximum daily evacuation was 5 to 8 times (58,1%). Most of the children showed a moderate dehydration (79,0?%), did not have fever (78,1%), and the duration of vomiting ranged from 1 to 4 days (74.2%). These results suggest that all electropherotypes behaved in a similar way and therefore did not provide information to establish the severity of the infection. Consequently it seems unlikely that the electropherotypes can be used to identify more virulent strains of rotavirus. Desde junio de 1993 a junio de 1995 se obtuvieron 377 muestras fecales de niños con diarrea aguda admitidos en el hospital Antonio Patricio de Alcala de Cumana, Venezuela. Se detectaron patrones electroforeticos de rotavirus en 27,85 por ciento (105/377) de las muestras, observandose que los patrones largos (80%) prevalecieron sobre los cortos (18,09%) y 2 especimenes (1,91%) exhibieron mezclas de electroferotipos. Por coelectroforesis se identificaron 6 patrones electroforeticos diferentes, 4 de patron largo y 2 de patron corto. Se encontro asociacion entre los electroferotipos detectados y las caracteristicas clinicas de la enfermedad, notandose una duracion de la diarrea de3a6 dias (73,8%), la evacuacion minima diaria fue1a2veces (85,4%) y la evacuacion maxima diaria fue 5 a 8 veces (58,1%). La mayoria de los ninos mostraron una deshidratacion moderada (79,0%), no tuvieron fiebre (78,1%) y la duracion de los vomitos fue de 1 a 4 dias (74,2%). Estos resultados sugieren que todos los electroferotipos se comportaron de manera similar y por lo tanto no proporcionaron informacion para establecer la severidad de la infeccion, por lo que parece improbable que los electroferotipos puedan ser usados para identificar cepas mas virulentas de rotavirus.