This paper presents the results of our case-based research into the causes and remedies of fresh produce supply chain disruptions resulting from contamination. The research was motivated by the incident of E-coli outbreak in packaged spinach in the US. We base our analysis on information gathered from published literature and data collection in the region from personnel involved in Agriculture. Our research is aimed at addressing the following research questions: What key factors contribute to the vulnerability to disruption from contamination and what are the interrelationships between these contributing factors? What managerial actions may be taken to minimize the fresh produce supply chain's vulnerability to disruption? In this research we develop a conceptual framework consisting of the contributing factors: product type, topological structure, exposure to contamination, product traceability, and communication. The practice related contributions of this research are managerial insight and recommended actions derived from the proposed conceptual framework.