dc.contributorGuzman-Ornelas, M.-O., Biomedical Sciences Doctorate Program, Sierra Mojada St 950, Ed C, PB Guadalajara, Jalisco, Mexico; Chavarria-Avila, E., Biomedical Sciences Doctorate Program, Sierra Mojada St 950, Ed C, PB Guadalajara, Jalisco, Mexico; Munoz-Valle, J.-F., Biomedical Sciences Doctorate Program, Sierra Mojada St 950, Ed C, PB Guadalajara, Jalisco, Mexico, Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara, Jalisco, Mexico; Armas-Ramos, L.-E., Master of Human Nutrition Program, University of Guadalajara, Guadalajara, Jalisco, Mexico; Castro-Albarran, J., Master of Human Nutrition Program, University of Guadalajara, Guadalajara, Jalisco, Mexico, HMIELM, Secretaria de Salud Jalisco, Guadalajara, Jalisco, Mexico; Aldrete, M.E.A., Biomedical Sciences Doctorate Program, Sierra Mojada St 950, Ed C, PB Guadalajara, Jalisco, Mexico, Department of Public Health, University of Guadalajara, Jalisco, Mexico; Oregon-Romero, E., Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara, Jalisco, Mexico; Mercado, M.V.-D., Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara, Jalisco, Mexico; Navarro-Hernandez, R.-E., Biomedical Sciences Doctorate Program, Sierra Mojada St 950, Ed C, PB Guadalajara, Jalisco, Mexico, Master of Human Nutrition Program, University of Guadalajara, Guadalajara, Jalisco, Mexico
dc.creatorGuzman-Ornelas, M.-O.
dc.creatorChavarria-Avila, E.
dc.creatorMunoz-Valle, J.-F.
dc.creatorArmas-Ramos, L.-E.
dc.creatorCastro-Albarran, J.
dc.creatorAldrete, M.E.A.
dc.creatorOregon-Romero, E.
dc.creatorMercado, M.V.-D.
dc.creatorNavarro-Hernandez, R.-E.
dc.date.accessioned2015-11-19T18:52:17Z
dc.date.accessioned2022-11-02T16:47:10Z
dc.date.available2015-11-19T18:52:17Z
dc.date.available2022-11-02T16:47:10Z
dc.date.created2015-11-19T18:52:17Z
dc.date.issued2012
dc.identifierhttp://hdl.handle.net/20.500.12104/67560
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84872307166&partnerID=40&md5=bdb43d8aa7fab947c05ea6d12d2d9213
dc.identifierhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=23118546
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5023501
dc.description.abstractPurpose: Obesity is a disease with genetic susceptibility characterized by an increase in storage and irregular distribution of body fat. In obese patients, the decrease in the Adiponectin gene (ADIPOQ) expression has been associated with a systemic low-grade inflammatory state. Our aim was to investigate the relationship between ADIPOQ +45T>G gene simple nucleotide polymorphism (SNP rs2241766) with serum adiponectin (sAdiponectin), distribution of body fat storage, and inflammation markers. Subjects and methods: In this cross-sectional study, 242 individuals from Western Mexico characterized as Mexican-Mestizo and classified by body mass index (BMI), were included. Anthropometrics, body composition, body fat distribution, and inflammation markers were measured by routine methods. Genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and sAdiponectin by the ELISA method. A P-value <0.05 was considered the statistically significant threshold. Results: sAdiponectin is associated with BMI (P< 0.001) and the genotypes (P, 0.001 to 0.0046) GG (8169 ± 1162 ng/mL), TG (5189 ± 501 ng/mL), and TT (3741 ± 323 ng/mL), but the SNP ADIPOQ +45T>G is not associated with BMI. However, the detailed analysis showed association of this SNP with a pattern of fat distribution and correlations (P<0.05) with inflammation markers and distribution of body fat storage (Pearson's r = -0.169 to -0.465) were found. Conclusion: In this study, we have suggested that the ADIPOQ +45G allele could be associated with distribution of body fat storage in obesity. On the other hand, as no association was observed between ADIPOQ +45T>G gene polymorphism and obesity, it cannot be concluded that the ADIPOQ +45G allele is responsible for the increase of adiponectin levels. © 2012 Guzman-Ornelas et al, publisher and licensee Dove Medical Press Ltd.
dc.relationDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
dc.relation5
dc.relation369
dc.relation378
dc.relationScopus
dc.relationMEDLINE
dc.titleAssociation of ADIPOQ +45t>g polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a mexican-mestizo population
dc.typeArticle


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