POTENCOR: A program to calculate power and correlation spectra of EEG signals

Abstract

The use of biomarkers as tools to evaluate genotoxicity is increasing recently. Methods that have been used previously to evaluate genomic instability are frequently expensive, complicated, and invasive. The micronuclei (MN) and nuclear abnormalities (NA) technique in buccal cells offers a great opportunity to evaluate in a clear and precise way the appearance of genetic damage whether it is present as a consequence of occupational or environmental risk. This technique is reliable, fast, relatively simple, cheap, and minimally invasive and causes no pain. So, it is well accepted by patients; it can also be used to assess the genotoxic effect derived from drug use or as a result of having a chronic disease. Furthermore the beneficial effects derived from changes in life style or taking additional supplements can also be evaluated. In the present paper, we aim to focus on the explanation of MN test and its usefulness as a biomarker; we further give details about procedures to perform and interpret the results of the test and review some factors that could have an influence on the results of the technique. " 2014 Olivia Torres-Bugarín et al.",,,,,,"10.1155/2014/956835",,,"http://hdl.handle.net/20.500.12104/43773","http://www.scopus.com/inward/record.url?eid=2-s2.0-84896944641&partnerID=40&md5=db9d0fb5d5eb58b072bf2b6c405ae84c

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24778463",,,,,,,,"Disease Markers",,,,"2014",,"Scopus

MEDLINE

WOS",,,,"Index Medicus;Animals;Biological Markers;Cell Nucleus/de [Drug Effects];Cell Nucleus/pa [Pathology];Cell Nucleus/re [Radiation Effects];Cytodiagnosis;DNA Damage;Humans;Micronuclei, Chromosome-Defective;Micronucleus Tests;Mouth Mucosa/pa [Pathology]",,,,,,,,"Potential uses, limitations, and basic procedures of micronuclei and nuclear abnormalities in buccal cells",,"Review" "45536","123456789/35008",,"Matsuoka, M., Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1, Aobacho, Higashimurayama, Tokyo 189-0002, Japan; Suzuki, Y., Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0021, Japan, Science and Technology Research Partnership for Sustainable Development, Japan Science and Technology, Japan International Cooperation Agency, Tokyo 102-0081, Japan; García, I.E., National School of Biological Science, IPN, Mexico; Fafutis-Morris, M., CIINDE Department of Physiology, CUCS, University of Guadalajara, Guadalajara, Mexico; Vargas-González, A., CIR Dr. Hideyo Noguchi, University Autonomous of Yucatan, Yucatan, Mexico; Carreño-Martinez, C., Leprosy Department, Mycobacterial Disease Prevention Programs, CENAVECE, Mexico; Fukushima, Y., Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0021, Japan; Nakajima, C., Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0021, Japan",,"Matsuoka, M.

Suzuki, Y.

García, I.E.

Fafutis-Morris, M.

Vargas-Gonzaalez, A.

Carrenao-Martinez, C.

Fukushima, Y.

Nakajima, C.",,"2010",,"Mexico is a country with sporadic leprosy cases, and the reemergence of drug resistance is a concern. In this study, molecular analysis of Mycobacterium leprae was employed to clarify the spread of drug-resistant leprosy. Thus, drug resistance-determining regions in the folP1, rpoB, and gyrA genes, which are associated with resistance to dapsone, rifampicin, and ofloxacin, respectively, were analyzed by direct sequencing of the PCR product. No mutations in the folP1 gene were observed in any of the 72 slit skin samples obtained from 38 patients, although two samples carrying a mutation at codon 425 in the rpoB gene, which confers resistance to rifampicin, a key component of multidrug therapy, were identified. In addition, a mutation at codon 91 in the gyrA gene, which correlates with ofloxacin resistance, was found in one sample. These results demonstrate the existence of rifampicin- and ofloxacin- resistant leprosy. Interestingly, wild-type and mutant sequences in the gyrA gene were found to coexist in one clinical sample. In addition, all three drug resistance-related mutations were found in only one of the two earlobes of the patients concerned, suggesting a possible pathway for the spread of drug-resistant M. leprae.",,,,,,,,,"http://hdl.handle.net/20.500.12104/43757","http://www.scopus.com/inward/record.url?eid=2-s2.0-78649617660&partnerID=40&md5=544b18b39966466da21eec98aa831628",,,,,,"6",,"Japanese Journal of Infectious Diseases",,"412

416",,"63",,"Scopus

WOS",,,,,,,,,,,,"Possible mode of emergence for drug-resistant leprosy is revealed by an analysis of samples from Mexico",,"Article" "45545","123456789/35008",,"Guevara, M.A., Instituto de Neurociencias, Universidad de Guadalajara, Rayo 2611, Colonia Jardines Bosque, C.P. 44520, Mexico; Ramos, J., Instituto de Neurociencias, Universidad de Guadalajara, Rayo 2611, Colonia Jardines Bosque, C.P. 44520, Mexico; Hernández-González, M., Instituto de Neurociencias, Universidad de Guadalajara, Rayo 2611, Colonia Jardines Bosque, C.P. 44520, Mexico; Zarabozo, D., Instituto de Neurociencias, Universidad de Guadalajara, Rayo 2611, Colonia Jardines Bosque, C.P. 44520, Mexico; Corsi-Cabrera, M., Facultad de Psicología, Univ. Nac. Auton. de Mexico, México, D.F., Mexico",,"Guevara, M.A.

Ramos, J.

Hernandez-Gonzalez, M.

Zarabozo, D.

Corsi-Cabrera, M.",,"2003",,"This work describes a computer program (POTENCOR) that applying the Fast Fourier Transform and Pearson product-moment correlation, can calculate easily, fast and accurately the absolute and relative power as well as the inter- and intrahemispheric correlation between every pair of EEG signals for narrow bands and for broad bands. POTENCOR has three main advantages: (1) it allows calculation of inter- and intrahemispheric correlation spectra, for which to our knowledge, there is no commercial program available; (2) the absolute and relative power values are not affected by the number of points that constitutes the signal segment; and (3) in case of making the analysis by each segment the temporal evolution for each EEG parameter can be graphically represented. The utility and flexibility of this program has been confirmed in many clinical and experimental researches. " 2002 Elsevier Science Ireland Ltd. All rights reserved.