dc.contributorLiras,G. Department of Internal Medicine, University Hospital, Guadalajara.
dc.creatorLiras G
dc.creatorCarballo F
dc.creatorDominguez-Munoz E
dc.creatorDe la Morena J
dc.date.accessioned2015-09-15T16:48:35Z
dc.date.accessioned2022-11-02T15:32:43Z
dc.date.available2015-09-15T16:48:35Z
dc.date.available2022-11-02T15:32:43Z
dc.date.created2015-09-15T16:48:35Z
dc.date.issued1995
dc.identifier1130-0108; 1130-0108
dc.identifierhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=7577123
dc.identifierhttp://hdl.handle.net/20.500.12104/37373
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5015320
dc.description.abstractOBJECTIVE: Quantification of circulating levels of granulocyte elastase has been shown to be a reliable method to predict severity of acute pancreatitis. The ELISA method until now available is, however, not easily applicable to the clinical routine. MATERIAL AND METHODS: In the present study we analyzed, retrospectively the clinical usefulness of an automated granulocyte elastase assay, the immunoactivation (IMAC) procedure, in predicting the course of acute pancreatitis, and we compared it with the ELISA method. PATIENTS: Plasma samples from 39 patients with acute pancreatitis, 18 with mild episodes and 21 with severe disease, were analyzed for granulocyte elastase concentration by both automated and manual ELISA procedures, on admission and on days 1, 2, 3, 5, 7 and 10. RESULTS: Automated elastase values did not differ statistically (Mann-Whitney test) from manual granuloma elastase values obtained by ELISA. Higher plasma elastase concentration was invariably found in severe pancreatitis when compared to mild cases. The optimal discriminating (severe vs mild illness) cutoff values were 200 micrograms/L on admission and 250 micrograms/L at 24 hours. Both assays showed similar prognostic reliability upper 90 per cent. CONCLUSIONS: Automated procedures enable faster and simpler granulocyte elastase determinations and exploit the benefits of this early and efficient prognostic marker.
dc.languageEnglish Spanish
dc.relationMEDLINE
dc.relationRevista Espanola de Enfermedades Digestivas
dc.relation87
dc.relation9
dc.relation641
dc.relation652
dc.titleClinical value of an automated granulocyte elastase assay in predicting severity of acute pancreatitis.
dc.typeJournal Article


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