Assessment of five thrombophilic gene polymorphisms in couples with habitual abortion [Evaluación de cinco polimorfismos de genes trombofZapotitlánlicos en parejas con aborto habitual]

dc.contributorQuintero-Ramos, A., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Valdez-Velázquez, L.L., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Hernández, G., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Baltazar, L.M., Facultad de Medicina, Universidad de Colima, Colima, Mexico; Padilla-Gutiérrez, J.R., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Valle, Y., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Rodarte, K., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Ortiz, R., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Ortiz-Aranda, M., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Programa de Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Olivares, N., Hospital General de Occidente, Secretaría de Salud, Guadalajara, Jalisco, Mexico; Rivas, F., Centro de Investigación Biomédica de Occidente IMSS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada No. 800, Col. Independencia, Guadalajara, Jalisco C. P. 44340, Mexico
dc.creatorQuintero-Ramos, A.
dc.creatorValdez-Velazquez, L.L.
dc.creatorHernandez, G.
dc.creatorBaltazar, L.M.
dc.creatorPadilla-Gutierrez, J.R.
dc.creatorValle, Y.
dc.creatorRodarte, K.
dc.creatorOrtiz, R.
dc.creatorOrtiz-Aranda, M.
dc.creatorOlivares, N.
dc.creatorRivas, F.
dc.date.accessioned2015-09-15T17:22:27Z
dc.date.accessioned2022-11-02T15:20:07Z
dc.date.available2015-09-15T17:22:27Z
dc.date.available2022-11-02T15:20:07Z
dc.date.created2015-09-15T17:22:27Z
dc.date.issued2006
dc.identifierhttp://hdl.handle.net/20.500.12104/39616
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33749065944&partnerID=40&md5=f9499dd76cbcb549b1a3cd5d0a1f71d1
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5012505
dc.description.abstractAn association between thrombophilic genes and obstetric conditions with early pregnancy termination has been previously proposed. In the present study we attempted to evaluate the possible association between thrombophilic genetic polymorphisms and habitual abortion (HA). Samples from two groups of volunteers were analyzed. The experimental group (n>100) was conformed by women attending the Centro Medico de Occidente, IMSS and their male couples, with a reproductive history of at least three miscarriages. The reference group (n>200) was composed by male and female healthy adults living in the state of Jalisco, Mexico. DNA was extracted from peripheral blood, and polymorphisms FII G20210A , FV G1691A, MTHFR C677T, ECA I/D y TNF G-308A were typed by PCR-RFLP or -SSP. Genotype proportions in the reference group were in agreement with the Hardy-Weinberg expectations. Allele, genotype, and phenotype proportion inter-group comparisons did not show statistically significant differences. The present results could not demonstrate that thrombophilic polymorphisms constitute risk factors for HA in Jalisco.
dc.relationScopus
dc.relationGaceta Medica de Mexico
dc.relation142
dc.relation2
dc.relation95
dc.relation98
dc.titleAssessment of five thrombophilic gene polymorphisms in couples with habitual abortion [Evaluación de cinco polimorfismos de genes trombofZapotitlánlicos en parejas con aborto habitual]
dc.typeArticle


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