Serum IgG activity against cyclic citrullinated peptide in patients evaluated for rheumatoid factor correlates with the IgM isotype

dc.contributorZavala-Cerna, M.G., Unidad de Investigaci�n M�dica en Epidemiolog�a Cl�nica, UMAE, IMSS, Guadalajara, Jalisco, Mexico, Doctorado Ciencias Biom�dicas, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Nava, A., Unidad de Investigaci�n M�dica en Epidemiolog�a Cl�nica, UMAE, IMSS, Guadalajara, Jalisco, Mexico, Direcci�n de Investigaci�n, Ciencias de la Salud, Universidad Aut�noma de Guadalajara, Guadalajara, Jalisco, Mexico; Garc�a-Casta�eda, E., Unidad de Investigaci�n M�dica en Epidemiolog�a Cl�nica, UMAE, IMSS, Guadalajara, Jalisco, Mexico; Dur�n-Gonz�lez, J., Programa de Doctorado en Gen�tica, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Arias-Merino, M.J., Laboratorio Cl�nico, UMAE, IMSS, Guadalajara, Jalisco, Mexico; Salazar-P�ramo, M., Divisi�n de Investigaci�n, UMAE, IMSS, Belisario Dom�nguez 1000, S.L. Col. Independencia, 44320 Guadalajara, Jalisco, Mexico, Departamento de Fisiolog�a, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
dc.creatorZavala-Cerna, M.G.
dc.creatorNava, A.
dc.creatorGarcia-Castaneda, E.
dc.creatorDuran-Gonzalez, J.
dc.creatorArias-Merino, M.J.
dc.creatorSalazar-Paramo, M.
dc.date.accessioned2015-09-15T18:55:34Z
dc.date.accessioned2022-11-02T15:19:23Z
dc.date.available2015-09-15T18:55:34Z
dc.date.available2022-11-02T15:19:23Z
dc.date.created2015-09-15T18:55:34Z
dc.date.issued2008
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-49949152389&partnerID=40&md5=30ab8267f04b02fee05d7a768b5ace51
dc.identifierhttp://hdl.handle.net/20.500.12104/44492
dc.identifier10.1007/s00296-008-0535-6
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5012347
dc.description.abstractThe purpose of this study was to evaluate the frequency of seric antibodies against cyclic citrullinated peptide (a-CCP) in patients tested for rheumatoid factor (RF) reactivity, and to analyze the correlation between their titers. We obtained serum from 112 consecutive patients (85 female), aged 47.2 � 13.4 years and from 46 clinically healthy subjects (CHS). Patients where stratified into four subgroups: rheumatoid arthritis (RA), probable RA (PRA), spondylarthropathies and other diagnosis. The a-CCP antibodies were determined by enzyme linked immunoassay (ELISA), RF by nephelometric test (IgM) and ELISA (IgG and IgM). Analysis of variance (ANOVA) showed statistically that a-CCP antibodies differs among RA versus CHS and other diagnosis; PRA versus CHS and other diagnosis. A significant Rho value of 0.84 (P < 0.05, Spearman's correlation) was identified between a-CCP antibodies and RF in PRA subgroup. When a correlation of a-CCP antibodies with RF (both isotypes) was done, the higher correlation was observed against IgM RF. The data suggests different pathways and times for each antibody generation. � 2008 Springer-Verlag.
dc.relationScopus
dc.relationWOS
dc.relationRheumatology International
dc.relation28
dc.relation9
dc.relation851
dc.relation857
dc.titleSerum IgG activity against cyclic citrullinated peptide in patients evaluated for rheumatoid factor correlates with the IgM isotype
dc.typeArticle


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