Invited tutorial: Metaheuristic optimization with applications to computational vision for humanoid robots

Abstract

Severe hemophilia A (HA) patients develop inhibitory alloantibodies to factor VIII:C and therefore require bypass agents that are scarce, expensive and may provoke secondary effects. Twenty-three severe HA patients who were high-responders to FVIII inhibitors were studied. FVIII:C activity in plasma was measured by one-stage activated partial thromboplastin time method, and the quantification of FVIII:C inhibitors was carried out by the Nijmegen-Bethesda method. Inhibition kinetics was assessed through serial plasma dilutions. FVIII:C activity was <1% in all patients. Kinetics behavior of the inhibitors was classified as type I in 14 patients, type II in four and an intermediate pattern that we named type III in one case. We were unable to apply the regression model to the remaining four of 23 patients in the study because of their low inhibitory titer (<3 Nijmegen-Bethesda units per ml). Seventy-eight percent of the patients with inhibitor type I did not respond to high doses of FVIII therapy, whereas 50% of patients with type II kinetics did (P = 0.5323). Generally, patients belonging to the same family had similar kinetics behavior as well as concordant treatment response. Although nonsignificant, our results suggest an association between kinetics behavior and treatment response that may be a valuable prognostic parameter for the management of these patients. " 2008 Blackwell Publishing Ltd.",,,,,,"10.1111/j.1751-553X.2008.01099.x",,,"http://hdl.handle.net/20.500.12104/42446","http://www.scopus.com/inward/record.url?eid=2-s2.0-74049115776&partnerID=40&md5=8ee95981ac8a627679e3ffb71596a3e7

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=18771497",,,,,,"6",,"International Journal of Laboratory Hematology",,"673

682",,"31",,"Scopus

MEDLINE

WOS",,,,"Index Medicus;Adolescent;Adult;Child;Child, Preschool;Factor VIII/ai [Antagonists & Inhibitors];Factor VIII/im [Immunology];Hemophilia A/dt [Drug Therapy];Humans;Infant;Kinetics;Middle Aged;Partial Thromboplastin Time;Treatment Outcome",,,,,,,,"Kinetics of factor VIII:C inhibitors and treatment response in severe hemophilia a patients",,"Article" "44160","123456789/35008",,"Perez-Cisneros, M., Department of Computational Sciences, Universidad de Guadalajara, Guadalajara, Mexico",,"Perez-Cisneros, M.",,"2011",,"Nature-inspired computing studies the application of biology concepts to solve demanding problems by assuming that natural world experiences may hold some answers to real-life technical challenges. Engineering is being challenged everyday by more complex, large, ill-structured and distributed systems yielding a renovated interest on the subject. However, nature is providing simple structures and organizations which are capable of dealing with most complex systems and tasks. Metaheuristic optimization techniques aims to mimic collective intelligence from several nature-inspired approaches in order to propose a solution for several problems exhibiting a complex behavioral pattern. The overall approach follows the idea that a system is composed of decentralized individuals that may effectively interact to other elements according to their localized knowledge, i.e. their individual interaction. Special kinds of artificial collective-individuals are the elements created by analogy with bees, charged particles or the human immunology system. " 2011 Author.