Genotoxic effect of chronic exposure to DDT on lymphocytes, oral mucosa and breast cells of female rats

dc.contributorCanales-Aguirre, A., Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of Jalisco, A.C. (CIATEJ), Normalistas 800, Guadalajara, 44270, Mexico; Padilla-Camberos, E., Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of Jalisco, A.C. (CIATEJ), Normalistas 800, Guadalajara, 44270, Mexico; Gómez-Pinedo, U., Laboratory of Regenerative Medicine, Neuroscience Institute, Hospital Clinico San Carlos, Madrid, 28040, Spain; Salado-Ponce, H., Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of Jalisco, A.C. (CIATEJ), Normalistas 800, Guadalajara, 44270, Mexico; Feria-Velasco, A., Biological Sciences Department, Biological and Agricultural Sciences Center, University of Guadalajara, Carr. a Nogales Km 15.5, Zapopan, 45110, Mexico, BiosMedica Cancer Research Institute, Alcatraces 72, Jardin Real, Zapopan, 45136, Mexico; de Celis, R., BiosMedica Cancer Research Institute, Alcatraces 72, Jardin Real, Zapopan, 45136, Mexico, Environmental Immunology Laboratory, Western Biomedical Research Center of the Mexican, Institute for Social Security, Sierra Mojada 800, Colonia Independencia, S.L., Guadalajara, 44340, Mexico
dc.creatorCanales-Aguirre, A.
dc.creatorPadilla-Camberos, E.
dc.creatorGomez-Pinedo, U.
dc.creatorSalado-Ponce, H.
dc.creatorFeria-Velasco, A.
dc.creatorde Celis, R.
dc.date.accessioned2015-11-19T18:50:03Z
dc.date.accessioned2022-11-02T14:48:38Z
dc.date.available2015-11-19T18:50:03Z
dc.date.available2022-11-02T14:48:38Z
dc.date.created2015-11-19T18:50:03Z
dc.date.issued2011
dc.identifierhttp://hdl.handle.net/20.500.12104/65097
dc.identifier10.3390/ijerph8020540
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79953278976&partnerID=40&md5=3b1ed4047a40861702d364fcab6804a1
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5004484
dc.description.abstractThe genotoxicity of some environmental contaminants may affect human health directly by damaging genetic material and thus plays an important role in cancer development. Xenoestrogens are one kind of environmental pollutants that may alter hormonal routes or directly affect DNA. The number of available biomarkers used to assess genetic risk and cancer is very extensive. The present study evaluated genotoxicity produced by the pesticide DDT on systemic and mammary gland cells obtained from adult female Wistar rats. Oral mucosa cells micronuclei were assessed; the comet assay in peripheral blood-isolated lymphocytes and mammary epithelial cells was also carried out. Additionally, oxidative stress was studied in mammary tissue through a lipid peroxidation assay. Our data showed an increase in lipid peroxidation, product of an increase in free oxygen radical levels, which leads to an oxidative stress status. Our results suggest that DDT is genotoxic, not only for lymphocytes but also to mammary epithelial cells. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
dc.relationInternational Journal of Environmental Research and Public Health
dc.relation8
dc.relation2
dc.relation540
dc.relation553
dc.relationScopus
dc.relationWOS
dc.titleGenotoxic effect of chronic exposure to DDT on lymphocytes, oral mucosa and breast cells of female rats
dc.typeArticle


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